质子泵抑制剂致药品不良反应分析

Analysis of Adverse Drug Reaction Induced by Proton Pump Inhibitors

目的:探讨质子泵抑制剂(PPIs)致药品不良反应(ADR)的特点及规律,为临床合理用药提供参考。方法:通过检索1998年1月—2011年6月中国医院数字图书馆(CNKI)收载的主要医药期刊报道的PPIs致ADR案例,得到符合标准的病例113例,并对其进行统计、分析。结果:PPIs所致ADR在41～50岁年龄组较多;用药后4～7d出现的ADR为31例;奥美拉唑致ADR例数最多,占76.99%;ADR可累及机体多个系统,以过敏反应最多(32例,占28.32%),严重者为过敏性休克;ADR预后总体较好。结论:临床应重视PPIs所致ADR,正确认识并全方位监测,可有效减少甚至避免ADR的发生。

OBJECTIVE： To discuss the characteristics and regularity of adverse drug reaction （ADR） induced by proton pump inhibitors （PPIs） and to provide guidance for its rational use in clinic. METHODS： 113 ADR cases induced by PPIs which were repotted in main medical journals published from Jan. 1998 to Jun. 2011 were collected by retrieving CNKI and analyzed statistically. RESULTS： The ADR cases induced by PPIs were mostly seen in the age from 41 to 50.31. ADR cases occurred within 4-7 days after medication; omeprazole led the first place in term of ADR incidence （76.99%）. The ADRs involved multiple systems, espe- cially allergic reaction （32 cases, 28.32% ）, most seriofls of them was allergic shock. The prognosis of ADR is generally good. CONCLUSION： Great importance should be attached to ADR induced by PPIs. Correct understanding and overall monitoring can effectively reduce or even avoid the occurrence of ADR.