非甾体抗炎药致肝功能损害病例分析

Analysis of Liver Function Damage Induced by NSAIDs

目的:对非甾体抗炎药致肝功能损害病例进行分析,为临床合理用药提供参考。方法:对1例成年女性Still病患者因使用非甾体抗炎药加重肝功能损害进行因果关系分析。结果:患者住院期间口服尼美舒利分散片和维C银翘片可能导致丙氨酸氨基转移酶(ALT)和天门冬氨酸氨基转移酶(AST)异常升高,经停药并予以还原型谷胱甘肽、多烯磷脂酰胆碱和异甘草酸镁治疗后,ALT和AST逐渐降低。结论:尼美舒利和维C银翘片应慎用于肝功能损害者,同时应定期监测患者肝功能。

OBJECTIVE： To analyze hepatic function damage induced by NSAIDs, and to provide reference for clinical drug use. METHODS： Causality judgment was used to analyze NSAIDs-induced hepatic function damage in a female adult with adult onset Still disease. RESULTS： Nimesulide dispersible tablet and Vitamin C yinqiao tablet taken by patient during hospital stay were likely to elevate the value of ALT and AST. So nimesulide and Vitamin C yinqiao tablet were discontinued immediately, ALT and AST decreased gradually after treatment of reduced glutathione, polyene phosphatidylcholine and magnesium isoglycyrrhizinate. CONCLUSION： Doctors should be prudent to prescribe nimesulide and Vitamin C yinqiao tablet to patients with hepatic function damage, and monitor hepatic function regularly.