摘要
目的明确清肝化痰活血方对非酒精性脂肪性肝炎(non-alcoholic steatohepatitis,NASH)患者的治疗作用。方法 NASH患者150例随机分为治疗组78例和对照组72例,治疗组给予清肝化痰活血方口服,对照组予胆宁片,共治疗3个月,观察两组治疗前后临床症状和体征、肝脏影像学、肝功能、血脂和胰岛素抵抗指数等变化。结果两组患者在临床症状、体重、体重指数、肝功能、血脂及肝脏B超积分等方面均有明显改善(P<0.05);治疗组胰岛素抵抗指数明显下降(P<0.05),在降低体重、体重指数、丙谷转氨酶、γ-谷氨酰转肽酶、甘油三酯、总胆固醇、肝脏B超积分及总有效率等方面均优于对照组(P<0.05)。结论清肝化痰活血方具有确切的治疗NASH的作用,疗效优于胆宁片。
Objective To observe the therapeutic effects of Qinggan Huatan Huoxue Recipe (QHHR) on patients with non-alcoholic steatohepatitis (NASH). Methods One hundred and fifty NASH patients were ran- domly assigned to the treatment group (78 cases) and the control group (72 cases). QHHR was given to pa- tients in the treatment groups, while Danning Tablet was given to those in the control group. The therapeutic course for all was three months. Before and after treatment changes of clinical symptoms and physical signs, liver imageology, liver functions, blood lipids, and insulin resistance index (IRI) were observed. Results Compared with before treatment, obvious improvement of clinical symptoms, weight, body mass index ( BMI), liver func- tions, blood lipids, and integral of liver ultrasound B was obtained in the two groups (P〈0.05). The IRI of the treatment group was significantly reduced after treatment (P 〈 0.05). Better effects were obtained in lowering the body weight, BMI, alanine aminotransferase (ALT), gamma glutamyltransferase (y-GT), triglyceride (TG), to- tal cholesterol (TC), integral of liver ultrasound B, and the total effective rate ( P 〈 0.05). Conclusions QHHR had definite effects on NASH. Its therapeutic effects were better than Danning Tablet.
出处
《中国中西医结合杂志》
CAS
CSCD
北大核心
2012年第1期29-31,共3页
Chinese Journal of Integrated Traditional and Western Medicine
基金
北京市中医药科技基金资助项目(No.JJ2005-19)
上海市卫生局资助课题(No.2004L003A)
关键词
清肝化痰活血方
非酒精性脂肪性肝炎
Qinggan Huatan Huoxue Recipe
non-alcoholic steatohepatitis