羟基乙酸联合1319nmNd:YAG激光面部除皱的临床及基础研究

Basic and clinical research of the treatment of wrinkle reduction in face used by glycolicacid and 1319nmNd:YAG laser

目的:观察羟基乙酸联合1319nmNd:YAG激光治疗面部皱纹的效果并探讨其除皱机制。方法:30例患者,随机分为两组,A组予果酸治疗组,B组为联合治疗组,予果酸联合1319nmNd:YAG激光治疗;选择40只SD大鼠,随机分空白对照组,光老化组,果酸治疗组及联合治疗组各10只,联合治疗组予果酸联合1319nmNd:YAG激光治疗并比较不同组大鼠皮肤组织学改变。结果:联合治疗组有效率达80%,而果酸治疗组达60%。组间有效率比较,差异具有统计学意义(χ2=3.801,P<0.05);联合治疗组高于果酸治疗组。造模光老化大鼠真皮胶原变性、断裂、减少、排列紊乱,经激光及果酸治疗后得到改善,联合治疗改善更明显。结论:1319nmNd:YAG激光联合羟基乙酸面部除皱疗效优于单纯羟基乙酸治疗。

： Objective To investigate the effectiveness of face and explore its possible mechanism. Methods 30 glycolicacid and 1319nm Nd：YAG laser in wrinkle reduction of patients were divided into two groups randomly. Group A was given only glycolicacid treatment, group B was treated with glycolicacid and 1319nmNd：YAG laser. At the same time 40 SDrats were randomly divided into control group, photoaged group,glycolicacid treatment group and laserglycolicacid treatment group,laser-glycolicacid treatment group was treated by 1319nmNd：YAG laser and glycolica- cid. Results The effectiveness ratio of two groups were 80.0%, 60.0% respectively, and there was a significantly statistic difference between them.（x2=3.801,P〈0.051.And the degeneration,reduction and disorder of dremal collagenimproved after 1319nm-Nd：YAG laser and glycolicacid treatment, laserglycolicacid treatment group was better in effect than glycolicacid treatment group. Conclusion 1319nm Nd： YAG laser comebined with glycolicacid had been proven to be better for wrinkle reduction in face.