乙酰辅酶A羧化酶在高尿酸血症合并腹型肥胖鹌鹑肝脏中的表达

Acetyl-CoA carboxylase expression in the liver of quail with hyperuricemia and abdominal obesity

采用高嘌呤饮食诱导鹌鹑高尿酸血症合并腹型肥胖模型，造模期间模型组鹌鹑体重未见明显变化。模型组鹌鹑第7、14、21、28天血尿酸水平显著升高（P〈0．05或P〈0．01）；第28天腹脂率显著升高；第7、28天血清游离脂肪酸水平显著升高；ELISA和免疫组化均显示第28天肝脏乙酰辅酶A羧化酶（ACC）蛋白表达显著升高（P〈0．05或P〈0．01），提示ACC表达的改变与高尿酸血症及腹型肥胖的形成有关。

The quail model of hyperuricemia combined with abdominal obesity was induced by high purine diet. Body weight in model group showed no change. Serum uric acid level in model group was increased significantly on 7, 14, 21 , and 28 d（ P〈0.05 or P〈0.01 ）. Abdominal fat index in model group increased significantly on 28 d. On 7 d and 28 d, sermn free fatty acid level was increased significantly. Acctyl-CoA carboxylase （ACC） protein expression in the liver of model quail was increased as shown by ELISA and immunohistochemisty （P〈0. 05 or P〈 0. 01 ） ,suggesting that the alteration of ACC expression contributes to the pathogenesis of hyperuricemia combined with abdominal obesity.