红花油对肥胖小鼠脂肪组织肥胖相关基因表达的影响

Effects of safflower oil on adipose-associated gene expression in mice

将70只C57BL／6小鼠分为对照组、猪油组、猪油改用红花油组和红花油组，第20周末取小鼠的脂肪组织作基因芯片检测。结果显示，猪油组小鼠的体重、血糖、血脂和血胰岛素较对照组明显升高（均P〈0．05）。改喂红花油后小鼠体重、血糖、血脂和血胰岛素明显降低（P〈0．05）；红花油可调节脂肪组织的增食欲基因、厌食基因和能量消耗基因，如阿片受体、胰升糖素和PPARa等。

Seventy C57BL/6 mice were divided into control group, lard group, lard transterred into safflower oil group, and safflower oil group. After 20 weeks, the white adipose tissues were taken to analyse the gene differentiational expression prolife. The results showed that body weight, blood glucose and lipids, and insulin levels in lard group were higher than those in control group（ all P〈0.05 ） , which were decreased after lard was transferred into safflower oil for 10 weeks（ all P〈0.05 ）. Safflower oil regulated some of the orexigenic genes, anorectic genes, and the genes involved in energy expenditure in adipose tissues such as opioid receptor, glucagon, and PPARa