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钙／钙调素依赖性蛋白激酶Ⅱ及其抑制剂在细胞生长调控中的作用及机制 被引量：1

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摘要 钙／钙调素依赖性蛋白激酶Ⅱ（ealeium／calmodulin-dependent proteinkinaseⅡ，Ca／CaMKⅡ）是钙／钙调节蛋白家族的一个主要成员，广泛分布于组织器官中，可通过调节G1／S期、G2／M期等有丝分裂节点调控细胞生长、增殖及分化的周期进程。近年来发现该分子活化可促进肿瘤发生和恶化，并与细胞耐药密切相关。CaMKⅡ抑制剂可通过抑制CaMKⅡ磷酸化，特异性抑制CaMKⅡ的活性，引起肿瘤细胞生长受抑或凋亡。对CaMKⅡ及其抑制剂的深人研究可有助于发现新的肿瘤靶向治疗途径。
作者 侯军 施菊妹（综述） 李楠（审校）
机构地区 同济大学附属第十人民医院血液科
出处 《国际输血及血液学杂志》 CAS 2012年第1期70-73,共4页 International Journal of Blood Transfusion and Hematology
基金 上海市卫生局资助项目（2010081）
关键词 钙/钙调素依赖性蛋白激酶Ⅱ 抑制剂 细胞周期 肿瘤
分类号 R749.16 [医药卫生—神经病学与精神病学]
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参考文献28

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同被引文献15

  • 1Morla AO,Mogford JE.Control of smooth muscle cell proliferationand phenotype by integrin signaling through focal adhesion kinase[J]. Biochemical and Biophysical Research Communications,2000,272(1):298-302.
  • 2Peng W,Zhang Y,Zheng M,et al .Cardioprotection by CaMKⅡdeltaB is mediated by phosphorylation of heart shock factor 1and subsequent expression of inducible heat shock protein 70[J]. Circulation Research,2010,106(1):102-108.
  • 3Singer HA.CaMKⅡ function in vascular remodeling[J].Physiol,2012,590(6):1349-1356.
  • 4House SJ,Ginnan RG,Armstrong SE,et al .Calcium/calmodulindependent protein kinase Ⅱ δisoform regulation of vascularsmooth muscle cell proliferation[J]. Am J Physiol Cell Physiol,2007,292(6):C2276-C2287.
  • 5Li W,Li H,Sanders PN,et al . The multifunctional CaMK Ⅱδcontrols neointima formation after carotid ligation and VSMCproliferation through cell cycle regulation by p21[J].Biol Chem,2011,286(10):7990-7999.
  • 6Ginnan R,Singer HA. CaM kinase Ⅱ dependent activation oftyrosine kinases and ERK1/2 in vascular smooth muscle[J].AmJ Physiol Cell Physiol,2002,282(4):C754-C761.
  • 7Webb DJ,Donais K,Whitmore LA,et al . FAK Src signalingthrough paxillin,ERK and MLCK regulates adhesion disassembly[J].Nat Cell Biol,2004,6(2):154-161.
  • 8Tokunou T,Ichiki T,Takeda K,et al .cAMP response elementbinding protein mediates thrombin induced proliferation ofVSMC[J]. Arterioscler Thromb Vasc Biol,2001,21(11),1764-1769.
  • 9Lemrow SM,Anderson KA,Joseph JD,et al .Catalytic activityis required for calcium/calmodulin dependent protein kinaseⅣto enter the nucleaus[J].J Biol Chem,2004,279(12):11664-11671.
  • 10Silfani FN,Freeman EJ. Phosphloinositide 3 kinase regulatesangiotensin 11 induced cytosolic phospholipase A2 activity andgrowth in vascular smooth muscle cells[J].Arch Biochem Biophys,2002,402(1):84-93.

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国际输血及血液学杂志
2012年 第1期

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