丹参酮Ⅱa磺酸钠对兔下颌骨牵张成骨促进作用的研究

Effect of Sodium Tanshinone ⅡA Sulfonate on Mandibular Distraction Osteogenesis in Rabbits

目的:探讨丹参酮Ⅱa磺酸钠注射液对兔下颌骨牵张成骨的作用。方法:将12只大耳白兔随机分为对照组和实验组,建立单侧兔下颌骨牵张成骨模型,实验组自牵张期开始每日注射丹参酮Ⅱa磺酸钠注射液3mL,并分别于固定期1周、4周、7周各处死2只对照兔和2只实验兔,对标本进行大体观察、X线观察、组织学观察和骨组织计量学观察。结果:实验组动物牵张间隙内新骨形成速度及质量均优于对照组,实验组成骨细胞活跃,骨小梁较成熟,单位面积内成骨细胞个数及骨小梁面积百分比均高于对照组。结论:丹参酮Ⅱa磺酸钠对兔下颌骨牵张成骨过程具有促进作用。

Objective： To study the effect of sodium tanshinone ]I A sulfonate on mandibular distraction osteogenesis in rabbits. Methods： 12 big-eared Japanese rabbits were randomly divided into control group （n= 6） and experimental group （n= 6）. Unilateral mandibular distraction osteogenesis models were established. Since the end of the delay period, the rabbits of the experiment group were injected sodium tanshinone Ⅱ A sulfonate 3ml every day. 2 control group rabbits and 2 experimental group rabbits were executed at different time points respectively （lweek, 4weeks, 7weeks after consolidation）. The general observation, X- ray observations, histology examination and the bone histomorphometry study were performed. Results： The formation rate and the quality of experimental group were superior to those of the control group. The osteoblast of experimental group was more active and the bone tra.- beculae were more mature. The number of osteoblasts and the percentage of trabeculae area in the distraction gap showed distinct increase compared to the control group（P〈0.05）. Conclusion： Sodium tanshinone ⅡA sulfonate appeared to be able to accelerate bone formation of mandibular distraction osteogenesis in rabbits.