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人附睾蛋白4在妇科肿瘤诊断及监测中的应用 被引量：16

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摘要 人附睾蛋白4(HE4)发现以来,国内外学者对HE4进行了一些相关研究,而日益增多的研究证据表明,HE4在卵巢癌和子宫内膜癌的早期诊断及疾病监测方面具有良好的应用前景,联合血清癌抗原125(CA125)检测,可进一步提高肿瘤诊断的敏感性和特异性,可为一个新的妇科肿瘤标志物。HE4在不同人群中的参考区间的确定,还有待于大规模的临床研究。
作者 蔡斌 席晓薇 丰有吉
机构地区 上海交通大学附属第一人民医院
出处 《实用妇产科杂志》 CAS CSCD 北大核心 2012年第1期25-27,共3页 Journal of Practical Obstetrics and Gynecology
关键词 人附睾蛋白4 肿瘤标志物 卵巢癌 子宫内膜癌
分类号 R737.3 [医药卫生—肿瘤]
  • 相关文献

参考文献13

  • 1Drapkin R,Von Horsten HH,Lin Y,et al.Human epididymis protein 4 (HE4) is a secreted glycoprotein that is overexpressed by serous and endometrioid ovarian carcinomas[J].Cancer Res,2005,65(6):2162-2169.
  • 2Galgano MT,Hampton GM,Frierson HF Jr.Comprehensive analysis of HE4 expression in normal and malignant human tissues[J].Mod Pathol,2006,19(6):847-853.
  • 3Hellstr(o)m I,Raycraft J,Hayden-Ledbetter M,et al.The HE4 (WFDC2)protein is a biomarker for ovarian carcinoma[J].Cancer Res,2003,63 (13):3695-3700.
  • 4Moore RG,Brown AK,Miller MC,et al.The use of multiple novel tumor biomarkers for the detection of ovarian carcinoma in patients with a pelvic mass[J].Gynecol Oncol,2008,108(2):402-408.
  • 5Moore RG,McMeekin DS,Brown AK,et al.A novel multiple marker bioassay utilizing HE4 and CA125 for the prediction of ovarian cancer in patients with a pelvic mass[J].Gynecol Oncol,2009,112(1):40-46.
  • 6董丽,昌晓红,叶雪,朱丽荣,赵旸,田莉,程洪艳,李小平,张虹,廖秦平,付天云,成夜霞,崔恒.血清人附睾分泌蛋白4和CA125水平检测在卵巢恶性肿瘤中的诊断价值[J].中华妇产科杂志,2008,43(12):931-936. 被引量：97
  • 7王术艺,谢永红,张杰,张红娟,李涛,李军良,金海红,张丽娜,赵淑艳.HE4和CA125联合检测在卵巢癌手术前后临床价值评价[J].河北医药,2009,31(5):564-565. 被引量：37
  • 8Havrilesky LJ,Whitehead CM,Rubatt JM,et al.Evaluation of biomarker panels for early stage ovarian cancer detection and monitoring for disease recurrence[J].Gynecol Oncol,2008,110 (3):374-382.
  • 9Kbel M,Kalloger SE,Boyd N,et al.Ovarian carcinoma subtypes are different diseases:implications for biomarker studies[J].Plo S Med,2008,5(12):e232.
  • 10卢仁泉,郭林,沈烨红.HE4在卵巢癌诊治中的临床应用评价[J].中国癌症杂志,2010,20(9):680-685. 被引量：39

二级参考文献43

  • 1Gadducci A, Cosio S, Carpi A, et al. Serum tumor markers in the management of ovarian, endometrial and cervical cancer. Biomed Pharmacother,2004,58 : 24 -38.
  • 2Meyer T, Rustin GJ. Role of tumour markers in monitoring epithelial ovarian cancer. Br J Cancer,2000,82 : 1535-1538.
  • 3Hellstrom I, Raycraft J, Hayden-Ledbetter M, et al. The HE4 (WFDC2) protein is a biomarker for ovarian carcinoma. Cancer Res, 2003,63 : 3695 -3700.
  • 4Israeli O, Goldring-Aviram A, Rienstein S, et al. In sihco chromosomal clustering of genes displaying altered expression patterns in ovarian cancer. Cancer Genet Cytogenet,2005 ,160 :35- 42.
  • 5Drapkin R, von Horsten HH, Lin Y, et al. Human epididymis protein 4 ( HE4 ) is a secreted glycoprotein that is overexpressed by serous and endometrioid ovarian carcinomas. Cancer Res, 2005, 65:2162-2169.
  • 6Kirchhoff C, Habben I, Ivell R, et al. A major human epididymisspecific cDNA encodes a protein with sequence homology to extracellular proteinase inhibitors. Biol Reprod, 1991,45: 350- 357.
  • 7Moore RG, Brown AK, Miller MC, et al. The use of multiple novel tumor biomarkers for the detection of ovarian carcinoma in patients with a pelvic mass. Gynecol Oncol,2008,108:402-408.
  • 8Zhang Z, Barnhill SD, Zhang H, et al. Combination of multiple serum markers using an artificial neural network to improve specificity in discriminating malignant from benign pelvic masses. Gynecol Oncol, 1999,73:56-61.
  • 9Woolas RP, Xu FJ, Jacobs IJ, et al. Elevation of multiple serum markers in patients with stage I ovarian cancer. J Natl Cancer Inst, 1993, 85:1748-1751.
  • 10Schutter EM, Davelaar EM, van Kamp GJ, et al. The differential diagnostic potential of a panel of turnout markers (CA125, CA15-3, and CA72-4 antigens) in patients with a pelvic mass. Am J Obstet Gynecol, 2002, 187: 385-392.

共引文献177

同被引文献104

  • 1曾蓉.CA125在上皮性卵巢癌筛查、疗效评价以及疾病监测中的意义及进展[J].药品评价,2012(9):30-34. 被引量：2
  • 2Kirchhoff C. Molecular characterization of epididymal pro- teins [ J]. Rev Reprod,1998 ,3 :86 -95.
  • 3Kirchhoff C,Habben I,Ivell R,et al.A major human epididymis-specific cDNA encodes a protein with sequence homology to extracellular proteinase inhibitors[J].Biol Reprod,1991,45(2):350-357.
  • 4Wang K,Gan L,Jeffery E,et al.Monitoring gene expression profile changes in ovarian carcinomas using cDNA microarray[J].Gene,1999,229(1-2):101-108.
  • 5Schummer M,Ng WV,Bumgarner RE,et al.Comparative hybridization of an array of 21,500 ovarian cDNAs for the discovery of genes overexpressed in ovarian carcinomas[J].Gene,1999,238(2):375-385.
  • 6Moore RG,Brown AK,Miller MC,et al.Utility of a novel serum tumor biomarker HE4 in patients with endometrioid adenocarcinoma of the uterus[J].Gynecol Oncol,2008,110(2):196-201.
  • 7Li J,Dowdy S, Tipton T,et al. HE4 as a biom 盯 ker for ovarI and endo-metrial cancer management[J]. Expen Rev Mol Diagn, 2009,9:555-566.
  • 8Anderson GL, Mclntosh M, Wu L, et al. Assessing lead time of selected ovarian cancer biomarkers:a nested case-control study [J]. J Natl Cancer Inst,2010,102(1) :26-38.
  • 9Wang K,Lu G,Jeffery E,et a. LMonitoring gene erpression pro- file change in ovarian carcinomas using cDNA microarray of genes involved in ovarian carcinogenesis[J]. Cancer Res, 2000, 60:5007-5011.
  • 10Drapkin R, yon Horsten HH, Lin Y, etal. Human epididymis protein 4 (HE4) is a secreted glycoprotcin that is overexpressed by serous and endometrioid ovarian carcinomas[J]. Cancer Res, 2005,65(6) :2162-2169.

引证文献16

二级引证文献100

实用妇产科杂志
2012年 第1期

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