多孔球形羟基磷灰石生物材料的制备

Preparation of Porous Spherical Hydroxyapatite Biomaterial

研究了一种作为药物载体的多孔球形羟基磷灰石生物材料的制备工艺。采用微乳液法先制得多孔球形碳酸钙,并以此为模板与磷酸氢二钠在一定条件下反应制备出直径约10μm的多孔球形羟基磷灰石。通过X射线衍射,扫描电子显微镜等手段对制备的羟基磷灰石的结构、组成和形貌进行表征,考察了不同反应温度、表面活性剂浓度、反应时间对多孔球形貌的影响,并对反应机理进行了初步探讨。结果表明,当制备多孔球形碳酸钙模板的温度为25℃、吐温-80浓度为3%且碳酸钙与磷酸氢二钠反应时间为30h时,得到的羟基磷灰石为5～10μm、分散性好的球形晶体。

The preparation of porous spherical hydroxyapatite （HAP） biomaterial used as drug delivery vehicle was investigated. The porous spherical HAP biomaterial was synthesized by a microemulsion reaction using porous spherical CaCO3 and Na2HPO4 as reac- tants. The obtained HAP was characterized by scanning electron microscopy and X ray diffraction, respectively. The effects of sur- factant concentration, synthesis temperature and time on the purity, particle size and morphology of HAP were investigated. The for- mation mechanism of porous spherical HAP was discussed. The results show that the well-dispersed porous spherical hydroxyapatite biomaterial with the particle size in the range of 5 to 10 μm could be prepared at the synthesis temperature of 25 ℃, the surfactant concentration of 3 % and the reaction time of 30 h.