蛋白质巯基亚硝基化与神经退行性疾病

Protein S-nitrosylation and neurodegenerative diseases

蛋白质巯基亚硝基化(S-nitrosylation,SNO)是指一氧化氮(NO)对蛋白质的半胱氨酸残基进行可逆性氧化还原修饰,这种修饰是NO在体内发挥作用的重要途径之一。近年来研究表明蛋白质SNO可以参与多种生理和病理过程,特别是一些靶蛋白的SNO参与神经退行性疾病发病过程及相关机制的研究倍受关注,该文对这方面近期研究进行概述。

S-nitrosylation is the reversible redox modification of nitric oxide（NO） acting on the protein＇s cysteine residues,which is an important way that NO plays a role in vivo.Recent studies have shown that it participates in a variety of physiological and pathological processes,especially the S-nitrosylation of some target proteins has been proven to be involved in neurodegenerative diseases,which is summarized in this paper.