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MicroRNAs对动脉粥样硬化关键信号分子的影响 被引量：3

MicroRNAs affected key signaling molecules of atherosclerosis
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摘要 microRNAs是近年来发现的内源性非编码单链RNA小分子,在心血管系统中具有特异性的表达谱,通过降解mRNA或抑制蛋白质翻译调控转录后基因的表达。microR-NAs在动脉粥样硬化形成的病理过程中,参与血管内皮细胞的损伤与修复;细胞炎性因子、生长因子等信号分子的表达与释放和血管平滑肌细胞的增殖与迁移等环节,从而调控动脉粥样硬化的发生发展。 Recently,microRNAs have been discovered as a small endogenous non-coding single-stranded RNA molecule,which has a specific expression profile in the cardiovascular system,and regulates gene expression at the transcriptional level through degradating mRNA or inhibiting protein translation.In the atherosclerosis,microRNAs attends not only vascular endothelial cell injury and repair,but also expression and release of cytokines,growth factors and other active substances,meanwhile,microRNAs attends vascular smooth muscle cell proliferation and migration and other aspects,thereby regulates atherosclerotic formation and development.
作者 袁绪胜 戴敏
机构地区 安徽中医学院药学院 安徽省中药研究与开发重点实验室 省部共建新安医学教育部重点实验室
出处 《中国药理学通报》 CAS CSCD 北大核心 2012年第1期20-23,共4页 Chinese Pharmacological Bulletin
基金 国家自然科学基金资助项目(No 81073090)
关键词 MICRORNAS 动脉粥样硬化 血管内皮细胞 血管平滑肌细胞 信号分子 基因表达 microRNAs atherosclerosis vascular endothelial cells vascular smooth muscle cells signaling molecules gene expression
分类号 R329.24 [医药卫生—人体解剖和组织胚胎学] R342.2 [医药卫生—基础医学]
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参考文献15

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二级参考文献24

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共引文献25

同被引文献55

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引证文献3

二级引证文献20

中国药理学通报
2012年 第1期

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