沙丁胺醇对急性心肌缺血模型大鼠心电图及血清心肌酶谱的影响

Effects of β_2 adrenergic receptor agonists on acute myocardial ischemia

目的:探讨β2肾上腺素受体激动剂沙丁胺醇(Salbutamol)对急性心肌缺血模型大鼠心电图及血清天冬氨酸转氨酶(AST)、乳酸脱氢酶(LDH)、肌酸激酶(CK)和超氧化物歧化酶(SOD)表达的影响。方法:采用舌下静脉注射垂体后叶素(1U/kg,6U/ml)的方法制备大鼠急性心肌缺血模型。静脉滴注5%葡萄糖500ml含沙丁胺醇(Salbutamol)0.18mg(滴速0.5ml/min),记录大鼠心电图J点位移及T波变化。测定血清AST、LDH、CK和SOD的含量。结果:β2受体激动剂Salbutamol恢复了由急性心肌缺血造成的心电图J点位移及T波变化值的异常改变,降低了心肌缺血大鼠血清AST、LDH和CK的水平,升高了血清SOD含量。结论:Salbutamol对急性心肌缺血具有一定的保护作用,该作用可能与降低肿瘤坏死因子-α的表达有关。

Objective： To observe the effects of β2 adrenergic agonists-salbutamol on the ECG and the levels of serum AST,LD,CK and SOD in the acute myocardial ischemia rats models.Methods： Injecting pituitrin（1U/kg,6U/ml） into sublingual vein simulated the acute ischemic rats models.Intravenous 5% glucose containing salbutamol 0.18 mg to record the displacement of J point and the changing of T wave.To determine the contents of serum AST,LDH,CK and SOD.Results： β2 adrenergic agonists-salbutamol reversed the abnormal changes of ECG induced by acute myocardial ischemia,and decreased the levels of serum AST,LDH,CK and SOD.Conclusion： Salbutamol have a certain protective effect on acute myocardial ischemia,which might involved with an downregulation of TNF2α.