婴儿母传麻疹抗体的动态观察及对麻疹疫苗的免疫应答

DYNAMIC OBSERVATION OF MOTHER-TRANSMITTED ANTI-MEASLES HI ANTIBODIES AND IMMUNE RESPONSE OF ATTENUATED MEASLES VACCINES

检测142对母、婴血清中的麻疹血凝抑制抗体(HI),结果有19对母、婴抗体均为阴性,7例低滴度(≤1∶4)抗体母亲的婴儿抗体也为阴性,麻疹抗体的阴性率母亲为13.4%,刚出生的婴儿为18.3%,抗体几何均值(GMT)分别为8.3和6.5.婴儿在3、5、7及8月龄时抗体累积阴性率分别为51.0%、78.1%、97.8%及100%.对母传麻疹抗体消失的14例3月龄、39例5月龄及21例7月龄婴儿进行沪_(191)麻疹减毒活疫苗接种,免疫1月后的抗体阳转率分别为57.2%、97.5%及100%.抗体GMT为12.34、18.89和22.23,在有麻疹患者的地区可考虑将免疫年龄提前到6月龄.

142 Pairs of sera from mothers and their infants were examined for HI antibodies. Seronegative was found in 19 Pairs and 7 infants born to mothers with HI antibodies lower than 1∶4.Seronegative rate was 13.4% in all the mothers and 18.3% in the infants. The GMTS of the HI antibodies were 8.3 in mothers and 6.5 in infants. Among the infants of 3、5、7、8 months old, the seronegative rates of the HI antibodies were 51%,78.1%,97.8% and 100% respectively. In the groups of 14 3-month old infants,39 5-month old infants and 21 7-month old infants, measles HI antibodies were all found to be negative. The above mentioned susceptiable infants groups were vaccinated with Shanghai 191 attenuated measles vaccine and, after one month's immunization, the positive rates of HI in these infants groups were 57.2%, 97.5% and 100%.Their GMTS were 12.34, 18.89, and 22.23 respectively. In measles epidemic areas measles vaccination is advised to be done when infants are 6 month old.