脂联素影响骨代谢致骨质疏松症的研究进展

Advances in studies on adiponectin affecting bone metabolism induced osteoporosis

使骨吸收增加或骨形成减少的因素都会诱导骨质疏松症的发生。脂联素作为近年来发现的一种内源性的生物活性多肽类物质,除观察到对糖脂代谢、血管内皮及平滑肌功能、肿瘤坏死因子等方面有作用外,在骨代谢中亦发挥重要作用,可直接或间接地影响骨吸收和骨形成这两大骨代谢方面。脂联素在骨组织中的生理作用的实质是对成骨和破骨两方面综合影响的结果。

At present, the factors which could increase bone absorption or inhitit osteogensis may induce the occurrence of osteoporosis disease. As an endogenous bioactive peptides discovered in recent years, adiponectin has the effect on glycolipid metabolism, function of vascular endothelial and smooth muscle, and tumor necrosis factor. Beyond these, adiponection also plays an important role in bone metabolism that could affect the bone absorption and osteogensis directly or indirectly. As a matter of fact, the action nf adinnnectin in physiological effect of bone tissue is a comprehensive influence on osteogenesis and broken bone essentially.