检测血心钠肽水平对舒张性心力衰竭的诊断意义

Diagnostic Value of Serum Atrial Natriuretic Peptide in Patients With Diastolic Heart Failure

目的:探讨测定血心钠肽(ANP)水平对诊断舒张性心力衰竭(DHF)的意义。方法:选择66例DHF患者作为实验组、64例非DHF的呼吸困难患者作为对照组,应用酶联免疫吸附测定法(ELISA)测定其血清ANP和脑钠素(BNP)水平,同时行心脏B超检查。并据ANP水平等对实验组和对照组进行分析判断。结果:DHF组的ANP水平明显高于对照组(P<0.05);以ANP高于正常值或正常值的2倍、3倍作为DHF判断标准时,均有统计学意义(P<0.05),并且以高于2倍时意义最大;联合试验ANP与BNP水平时能明显提高DHF的诊断价值。结论:测定ANP可能对DHF有较好的诊断价值。联合检测ANP和BNP水平可提高DHF的诊断准确性。

Objective： To investigate the diagnostic value of serum level of atrial natriuretic peptide （ ANP） in patients with diastolic heart failure （ DHF） . Methods： Sixty-six patients with DHF were selected as experimental group,64 patients with dyspnea but without DHF as control group. Levels of ANP and brain natriuretic peptide （ BNP） were detected by enzyme linked immunosorbent assay （ ELISA） . Ultrasonic cardiac examination was made as well. Results： Serum levels of ANP in patients with DHF were significantly higher than that without DHF （ P 0. 05） . There was statistical significance when it was considered that ANP was higher than normal or double or triple than normal value as a criteria of diagnosis of DHF （ P 0. 05） . Combined determination of serum levels of ANP and BNP would help to increase the diagnostic value for DHF. Conclusions： Serum level of ANP is a good predictor for diagnosis of DHF. Combined detection of serum levels of ANP and BNP will help to increase the accuracy for diagnosis.