化妆品过敏患者全血与致敏物中铬的相关性分析

Correlation analysis of chromium contents in whole blood and cosmetics of patients with cosmetic contact dermatitis

目的:为了解化妆品中铬产生的危害性,对疑似化妆品接触性皮炎患者血样和接触物进行铬含量分析,探讨两者相关性。方法:临床确诊36名化妆品接触性皮炎患者发病期静脉血和可疑化妆品130份,用石墨炉原子吸收光谱法检测铬含量,用SPSS 15.0进行统计分析。结果:44.6%(58/130)的化妆品和22%(8/36)患者接触的26份化妆品未检出铬;78%(28/36)过敏患者一次性同时接触含铬化妆品1份～6份,铬含量范围0.009 mg/kg～36 mg/kg;患者全血中铬含量在1.0 ng/ml～72 ng/ml,为正常范围内;过敏患者全血与其接触化妆品中的铬含量两者间相关系数r=-0.054,(P>0.05)。4例血铬阴性者接触的16例化妆品中铬阴性。结论:化妆品过敏患者全血与可疑化妆品中铬含量无明显相关关系。化妆品中的铬可能是78%过敏患者的致敏原。

Objective：To find the hazard caused by chromium to the patients with cosmetic contact dermatitis and analyze the correlation of chromium contents in whole blood and cosmetics of these patients.Methods： 36 patients with cosmetic contact dermatitis were chosen randomly,samples of their venous blood and suspect cosmetics were extracted and collected.Microwave digestion-graphite furnace atomic absorption spectrometry was used to detect the chromium contents in blood and cosmetics and SPSS 15.0 was used to analyze the results.Results： The chromium was negative in 44.6% of the cosmetics（58/130） and 22% of the patients（8/36） who had contacted 26 cosmetic samples.78%（28/36） of the patients used 1~6 cosmetics which contained chromium at the same time and the chromium contents were 0.009 mg/kg^36 mg/kg.The chromium contents in whole blood of the patients were 1.0 ng/ml^72 ng/ml within the normal range.The related coefficient of chromium contents in whole blood and cosmetics of cosmetic contact dermatitis patients was-0.054（r=-0.054,P 0.05）.Chromium was not detected in the whole blood of four patients and their 16 cosmetics.Conclusion： There was no obvious correlation between chromium contents in whole blood and cosmetics of cosmetic contact dermatitis patients.Chromium in cosmetics was the allergen of 78% of the patients.