CEA NSE CYFRA21-1三项血清标志物在肺癌诊断中的应用

Application of three serum markers CEA,NSE and CYFRA21-1 in study of lung cancer

目的:探讨联合检测血清肿瘤标志物癌胚抗原(carcinoembryonic antigen,CEA)、神经元特异性烯醇化酶(neurons specificenolase,NSE)、细胞角蛋白19片段(CYFRA21-1)在肺癌诊断中的应用价值。方法:对74例肺癌组,46例健康对照组,33例肺部良性疾病组,采用电化学发光法进行CEA、NSE、CYFRA21-1检测并对比分析。结果:肺癌组的三项肿瘤标志物水平均高于肺良性疾病和健康对照组。CEA、NSE、CYFRA21-1分别在腺癌、小细胞癌、鳞癌中表达水平最高,其阳性率分别为82.6%、81.3%、68.6%,与其他单项肿瘤标志物比较差异有统计学意义(P<0.05),且三项联合检测对肺癌诊断敏感性明显高于单项标志物。结论:血清CEA、NSE和CYFRA2I-1的联合检测有助于临床对肺癌的诊断,并对组织分型有较高的参考价值。

Objective：To study the application value of joint test of serum tumor markers carcinoembryonic antigen（CEA）,neurons specific enolase（NSE） and cytokeratin 19 fragment（CYFRA21-1） in the diagnosis of lung cancer.Methods：The CEA,NSE and CYFRA21-1 detections in 74 cases of lung cancer,46 cases of healthy controls and 33 cases of benign lung disease were performed by the electrochemical luminescence method and the results were compared.Results：The three tumor markers in the lung cancer group were higher than those in the benign lung disease group and healthy controls.CEA,NSE and CYFRA21-1 were highest in gland cancer,small cell carcinoma and squamous cell carcinoma,their positive rates were 82.6%,81.3% and 68.6% respectively,showing significant difference compared with other single tumor markers（P0.05）.And the sensitivity of 3-item combination detection to lung cancer diagnosis was obviously higher than that of single marker.Conclusion：The joint test of serum CEA,NSE and CYFRA2I-1 is helpful to the clinical diagnosis of lung cancer with higher reference value to the histologic classification.