阿托伐他汀联合贝那普利治疗高血压合并蛋白尿的疗效观察

Combination of atorvastatin and benazepril in treating hypertension complicating proteinuria

目的:探讨阿托伐他汀联合贝那普利对高血压合并蛋白尿的疗效。方法:135例患者依就诊次序分为3组,阿托伐他汀组(阿托伐他汀,20 mg/d),贝那普利组(贝那普利,10 mg/d)以及联合用药组(每天20 mg阿托伐他汀和10 mg贝那普利)。各组分别在治疗前,治疗6个月和治疗12个月后检测患者的血压、血脂、血肌酐、24 h尿蛋白量、尿酸和ALT等指标。结果:与治疗前相比较,联合用药组治疗后(6个月和12个月)能显著下调患者的血压、血脂、血肌酐、24 h尿蛋白量和尿酸(P<0.05),阿托伐他汀组治疗后能显著下调患者的血脂、血肌酐、24 h尿蛋白量和尿酸(P<0.05),贝那普利组治疗后能显著下调患者的血压、血肌酐、24h尿蛋白量和尿酸(P<0.05)。治疗后,与阿托伐他汀组或贝那普利组相比较,联合用药组患者的血脂,血肌酐和24h尿蛋白量的降幅显著(P<0.05)。结论 :阿托伐他汀联合贝那普利治疗高血压合并蛋白尿具有满意的疗效,且使用安全,值得临床推广。

Objective:To investigate the effects of combining atorvastatin and benazepril for treating hypertension complicating proteinuria.Methods:A total of 135 patients were allocated into three groups randomly,atovastatin group(atovastatin,20 mg/d),benazepril group(benazepril,10 mg/d) and combination group(20 mg/d of atovastatin and 10 mg/d of benazepril).The parameters such as blood pressure,blood lipid,serum creatinine,proteinuria,uric acid and GPT were measured before treatment and at 6,12 months after treatment.Results:Compared with before treatment,blood pressure,blood lipid,serum creatinine,proteinuria and uric acid in the combination group at 6,12 months after treatment were significant decreased(P<0.05).Blood lipid,serum creatinine,proteinuria and uric acid at 6,12 months after treatment in the atovastatin group were significant decreased(P<0.05),while blood pressure,serum creatinine,proteinuria and uric acid in the benazepri group were significant decreased(P<0.05).Compared with single medicine groups(atorvastatin or benazepril0,the decrement of blood lipid,serum critinine,24 h urine protein and uric acid in the combination group was more significant.Conclusion:Combination of atovastatin and benazepril has satisfying clinical effect for treating hypertension complicating proteinuria with medication safety,which is worthy of being popularized in clinic