青年结直肠癌的临床及病理学特点分析

Youth Colorectal Carcinoma：Clinical and Pathological Characteristics Analysis

为探讨青年结直肠癌的临床及病理学特征，回顾分析2001年1月至2008年6月收治的50例青年结直肠癌患者的资料，并与同期老年结直肠癌患者进行对比。结果显示，两组患者的性别构成、病灶部位、3年存活率比较差异无统计学意义，P〉0．05；与老年结直肠癌患者比较，青年患者并存病少、临床表现不典型、病程长、首诊确诊比例少、确诊时间长、手术治疗多、Dukes分期高，P〈0．05。结果表明，青年结直肠癌患者有自身临床及病理学特点，应加强对青年结肠癌临床特点的了解和认识，诊疗过程中重视肠镜检查及直肠指检，其治疗首选手术治疗，术后配合放疗和化疗必不可少。

In order to explore the clinical and pathological features of youth colorectal carcinoma, author retrospectively analysed the data from the 50 patients with youth colorectal carcinoma, who had received treatment from Jan. 2001 yr. to Jun. 2008 yr. and compared them with senile colorectal carcinoma at same time. As results,in sex ratio, lesion locus, 3-year survival rate there was no statistical difference between both groups （ P 〉0.05） ;meanwhile compared with senile patients youth patients had less concurrent dis- eases. Their clinical manifestations were atypical, the disease course was longer, the ratio of first confirmed cases was less, confirmed diagnosis needed longer time, treatment more adapted operation, and with higher Dukes stage（ P 〈0. 05）. Results show that youth colorectal carcinoma possess its inherent clinical and pathological features, so that it should be to strengthen understanding and studying the clinical features of this disease,during diagnosis and treatment to lay stress on enteroscope exam. and rectal digital examsurgical treatment should be taken as the first choice of its treatment, and postoperative adjuvant radiation and chemotherapy are necessary.