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抑制肿瘤干细胞生长的策略研究

Strategies of Inhibiting Growth for Cancer Stem Cell
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摘要 肿瘤干细胞假说认为,肿瘤的复发和转移与肿瘤干细胞残存有密切关系。近几年的研究发现,肿瘤干细胞高表达ABC转运蛋白、抗凋亡基因高水平表达、端粒酶活性高、DNA修复能力增强,因而对放化疗不敏感,容易导致肿瘤的复发和转移。抑制肿瘤干细胞生长的微环境、抑制ABC转运蛋白的活性、阻断信号转导、导入溶瘤病毒、抑制端粒酶活性等方法抑制肿瘤干细胞将为肿瘤的临床治疗提供新的策略。
出处 《肿瘤学杂志》 CAS 2011年第11期863-865,共3页 Journal of Chinese Oncology
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