农村接受抗病毒治疗艾滋病病人生活质量评估

Life Quality Assessment of People living with AIDS Who Received Antiretroviral Treatment(ART)

目的评价接受抗病毒治疗的艾滋病病人的生活质量,为提高他们的生活质量提供依据。方法对安徽省抗病毒治疗效果评估队列的艾滋病人及其邻居进行问卷调查。问卷包括一般情况和36条目简明量表(SF-36)中文版进行生活质量评价。结果共调查艾滋病病人110人,对照邻居114人。两组人群在年龄、性别、家庭人口数、职业等方面情况类似,但在婚姻状况、文化程度、个人收入、家庭收入、自觉家庭经济状况等方面,艾滋病病人相对较为弱势。在所有的生活治疗的8个领域中,艾滋病病人的得分均显著低于对照邻居。艾滋病病人和对照邻居的生理生活质量得分分别是47.1±18.5和75.9±22.1(t=-10.390,P<0.001),心理生活质量得分分别为51.3±21.7和80.7±19.2(t=-10.484,P<0.001)。多因素逐步回归分析显示,组别、性别和年龄等变量与生理生活质量相关,组别、性别和自评家庭经济状况等变量与心理生活质量相关。而在艾滋病病人中,仅病毒载量分别与生理生活质量和心理生活质量相关。结论艾滋病对个人和家庭的影响显著,尤其是在经济方面;艾滋病病人的生活质量显著降低,艾滋病对生活质量的影响巨大且覆盖了常见危险因素的影响。

Objective To assess the quality of life（QOL） of people living with AIDS（PLWA） who were or antiretroviral treatment（ART）.Method A questionnaire survey was conducted among Anhui ART assessment cohort and their neighbors.The questionnaire included basic demographic information and QOL SF-36 form to assess QOL.Results There were 110 PLWAs and their 114 neighbors in the study.The two subgroups were similar in terms of age,gender,family size,occupation,but PLWAs were inferior to their neighbors in terms of marital status,educational level,personal income and family income.The PLWAs had lower QOL scores in all 8 SF-36 fields than their neighbors.The PLWAs and their neighbors had the PSS scores of 47.1±18.5 and 75.9±22.1（t=-10.390,P0.001）and had the MSS scores of 51.3±21.7 and 80.7±19.2（t=-10.484,P0.001）.multi-variate regression analysis revealed that group,gender and age were related to PSS,group,gender and family income were related to MSS.Among PLWAs,only viral load level was related to PSS and MSS respectively.Conclusion The study found that AIDS had affected PLWAs and their families,especially on economic status,AIDS had significantly reduced QOL of PLWAs and covered the risk of other factors.Further studies are needed to identify the risk factors of QOL of PLWAs in areas with many former plasma donors.