高胆固醇血症红细胞膜CD35、CD44s、CD59分子表达研究

Study of CD35,CD44s,and CD59 of human erythrocytes cytomembrane in hypercholesterolemia

目的探讨高胆固醇血症红细胞膜表面CD35、CD44s、CD59分子的表达及意义。方法采用对照研究方法,选取高胆固醇血症(>6 mmol/L)业健康者和对照组各32例,流式细胞仪观察红细胞膜表面CD35、CD44s、CD59分子变化特征。结果高胆固醇组红细胞膜CD35、CD44s、CD59平均荧光明显低于对照组,差异有统计学意义。结论高胆固醇血症红细胞膜CD35、CD44s、CD59分子表达降低,导致其免疫调控功能紊乱,可能是启动动脉粥样硬化的原因之一。

Objective To study the CD35, CD44s, CD59 molecular weight distribution of erythrocyte cytomembrane in hypercbolesterolemia. Methods The CD35, CD44s, and CD59 molecular weight distribution in erytbrocytes of 32 sub - healthy subjects with hypercholesterolemia（ 〉 6mmol/L） was observed by flow cytometry and compared with that of control group. Results Compared with normal group, the CD35, CDd4s, and CD59 average fluorescence intensity was reduced. Conclusions The reduction of CD35 ,CD44s, CD59 molecular weight distribution resulting in immune regulation functional disorder may be one of the causes of atherosclerosis.