高血压4种治疗方案的成本-效果分析

Cost - effectiveness analysis of four therapeutic schemes for hypertension

目的评价高血压4种治疗方案的疗效及经济学效果。方法筛选到我院就诊的高血压患者201例,根据不同的治疗方案分为4组:A组,硝苯地平缓释片;B组,厄贝沙坦片;C组,盐酸贝那普利片;D组,苯磺酸氨氯地平片。观察4组的疗效、记录不良反应,并进行成本-效果分析。结果 A、B、C、D组总有效率分别为68.8%、72.0%、94.5%、98.0%,不良反应发生率分别为6.3%、8.0%、9.3%、6.1%,成本-效果比分别为1.37、4.20、4.39、3.09,B、C、D组相对于A组的增量成本-效果比分别为64.98、12.45、7.12。结论采用硝苯地平缓释片治疗高血压病疗效好且更为经济。

Objective To compare the therapeutic effect and economic effectiveness of four hypertensive therapeutic programs. Methods 201 hypertensive patients were randomly divided into four groups according to therapeutic schemes：（A） Extended release nifedipine tablets ; （B） Irbesartan tablets ; （C） Benazepril hydrochloride tablets ; （D） Amlodipine besylate tablets. The therapeutic efficacy in the four groups was observed after oral administration and the cost - effectiveness analysis was conducted. Results The total effective rate in the tbur groups （ A,B,C and D） was 68.8% , 72.0%, 94. 5% , and 98.0% , respectively. The incidence rate of ADR（adverse drug reaction） was 6. 3% , 8.0% , 9. 3% ,and 6. 1% , respectively. The cost - effectiveness ratio was 1.37, 4. 20, 4. 39 and 3.09, respectively. The incremental cost - effectiveness ratio of group B, C and D to group A was 64. 98, 12.45 and 7. 12. resnectivelv. Conclusions Scheme A is superior to the other three therapeutic schemes.