基准剂量软件BMDS中连续模型的研究

The Continuous Models in Benchmark Dose Software

对美国环境保护署开发的基准剂量软件BMDS的2.1.1版中连续模型进行了剖析,详细介绍了模型形式;参数初始值的设置、估计方法、标准误、置信上下限;全模型、残差模型和拟合模型的对数似然函数、模型的显著性检验;各剂量下概率的预测、残差;两种风险模式下基准剂量的计算方法,并将计算结果与BMDS软件的计算结果进行比较,结果表明本文介绍的计算方法的正确性,为下一步进行软件设计奠定了理论基础.

The continuous models in the U.S.Environment Protection Agency Benchmark Dose Software were researched in this paper,including the form of the model,initial parameter value,estimated method,confidence limit;Log likelihood function;prediction;BMD under two risk mode.The result of an example indicated that our calculated formula was consistent with the BMDS.