克拉玛依市特殊人群麻疹抗体水平及免疫效果研究

Epidemiological study of measles antibody among women of childbearing age and infants in Kelamayi

目的了解育龄期女性、产妇及婴幼儿人群麻疹抗体水平分布,为制订预防策略提供依据。方法 2009年至2010年,选取育龄期妇女、产妇、新生儿及5～8月龄婴儿,采集血清用ELISA法进行麻疹抗体IgG水平检测,同时对5～8月龄婴儿进行麻疹疫苗免疫效果研究。结果育龄期妇女IgG抗体阳性率82.98%、保护率49.64%;产妇阳性率85.00%、保护率52.14%;新生儿阳性率79.17%、保护率47.50%,育龄期妇女与产妇间阳性率、保护率差异无统计学意义(χ2=0.27,P>0.05;χ2=0.23,P>0.05),GMT无明显变化。产妇与新生儿间阳性率、保护率差异无统计学意义(χ2=0.43,P>0.05;χ2=0.27,P>0.05),GMT无明显变化。5、6、7、8月龄婴儿免疫后抗体阳转率及抗体4倍增长率间差异无统计学意义(χ2=2.27,P>0.05;χ2=0.064,P>0.05);各组间GMT无明显趋势。结论建议在麻疹非流行期,为育龄期妇女接种麻疹疫苗。而在麻疹流行时,可将免疫初始月龄提前至6月龄。

Objective To investigate measles antibody levels among women of childbearing age and infants in Kelamayi.Methods Serum specimens were collected from 282 women of childbearing age（23-30 years）,140 new mothers（25-34 years）,120 newborns and 324 infants aged 5-8 months in 2009 and 2010.The levels of measles antibody were detected by ELISA.Results Measles antibody was detected in 82.98% of women of childbearing age,85.0% of new mothers and 79.17% of newborns,respectively.The protective levels of measles antibody were confirmed in 49.64% of women of childbearing age,52.14% of new mothers and 47.50% of newborns,respectively.The rates of measles antibody seroconversion were 80.95%,84.21%,90.24% and 90.74%,respectively for infants aged 5-8 months old after immunization.Conclusion The results suggested the importance of measles vaccination for the women of childbearing age.