血清β_2-MG与甲状腺癌的相关性研究

The Relationship of Serum β_2-Microglobulin with Thyroid Cancer

[目的]探讨血清β2-微球蛋白(β2-microglobulin,β2-MG)与甲状腺癌相关性。[方法]选择正常人群1002例、甲状腺癌95例、结节性甲状腺肿243例,采用ELISA双抗体夹心法检测血清β2-MG含量。[结果]正常人群β2-MG阳性率7.78%(78/1002),结节性甲状腺肿阳性率7.81%(19/243),甲状腺癌阳性率31.57%(30/95)。甲状腺癌组与正常人群组(χ2=55.352,P<0.001)及结节性甲状腺肿组(χ2=31.106,P<0.001)差异有显著性,结节性甲状腺肿组与正常人群组差异有显著性(χ2=0.0004,P=0.986)。不同病理类型(χ2=10.015,P=0.007)、有无淋巴结转移(χ2=4.441,P=0.035)和远处转移(χ2=9.795,P=0.002)甲状腺癌组间β2-MG阳性率有显著性差异。[结论]甲状腺癌患者血清β2-MG水平较高,病理类型、淋巴结转移、远处转移影响血清β2-MG水平。

[Purpose] To investigate the relationship of serum β2-microglobulin（β2-MG）with thyroid cancer.[Methods] One thousand and two healthy person,95 cases with thyroid cancer and 243 cases with nodular goiter were enrolled.The serum β2-MG level was detected by double-antibody sandwich ELISA assay.[Results] The positive rate of β2-MG in healthy person,nodular goiter group and thyroid cancer group was 7.78%（78/1002）,7.81%（19/243） and 31.57%（30/95） respectively.There was significant difference between thyroid cancer group and healthy person group（χ2=55.352,P0.001） or nodular goiter group（χ2=31.106,P0.001）.There was not significant difference between healthy person group and nodular goiter group（χ2=0.0004,P=0.986）.The positive rate β2-MG in thyroid cancer patients with different pathological types（χ2=10.015,P=0.007）,positive and negative lymph node（χ2=4.441,P=0.035） and with and without distant metastasis（χ2=9.795,P=0.002） had significantly different.[Conclusion] The serum β2-MG level in thyroid cancer patients is high.Pathological type,lymph node metastasis and distant metastasis are the influencing factors of serum β2-MG.