炔雌醇环丙孕酮治疗子宫内膜息肉样增生的临床观察

Efficacy and Safety of Ethinylestradiol and Cyproterone Acetate Tablets for Polypoid Endometrial Hyperplasia

目的:比较炔雌醇环丙孕酮与高效合成孕激素炔诺酮(妇康片)治疗子宫内膜息肉样增生的疗效、不良反应及患者依从性。方法:160例患者在治疗前均已行宫腔镜检查、病理确诊,以随机抽样法分为对照组和治疗组各80例。对照组采用高效合成孕激素炔诺酮治疗,治疗组给予炔雌醇环丙孕酮治疗。结果:治疗组80例患者中有74例月经恢复正常,治疗后再次行宫腔镜检查及子宫内膜病检,显示子宫内膜正常,占92.5%;对照组80例患者中有58例月经恢复正常,治疗后再次行宫腔镜检查及子宫内膜病检,显示子宫内膜正常,占72.5%,2组比较差异显著,有统计学意义(P<0.01)。患者依从性比较,治疗组明显高于对照组,差异有统计学意义(P<0.01)。2组药品不良反应比较无明显差异,无统计学意义,P>0.05。结论:应用炔雌醇环丙孕酮治疗子宫内膜息肉样增生治愈率高,且患者依从性高,是治疗子宫内膜息肉样增生方便、有效、经济的治疗方法。

OBJECTIVE：To evaluate the efficacy and safety of Ethinylestradiol and Cyproterone Acetate Tablets vs.Norethisterone（norlutin） in the treatment of polypoid endometrial hyperplasia and observe patients＇drug compliance.METHODS： A total of 160 patients who have been undergone hysteroscopy and the pathological diagnosis before treatment were randomly assigned to either treatment group treated with Ethinylestradiol and Cyproterone Acetate Tablets or control group with Norethisterone,of 80 each.RESULTS： After treatment,74 patients in the treatment group vs.58 of the control group had normal menstruation,and 92.5% vs.72.5% showed normal endometrium in post-treatment pathological examination,showing significant differences between the two groups（P0.01）.The treatment group showed significantly higher drug compliance than did the control group（P0.01）.No significant differences were noted between the two groups in frequency of adverse drug reactions（P0.05）.CONCLUSION： The patients with polypoid endometrial eyperplasia showed higher cure rate and good compliance to the therapy of Ethinylestradiol and Cyproterone Acetate Tablets,which thus is a convenient,effective and economic regimen for polypoid endometrial eyperplasia.