昆山地区早产儿影响因素1:3病例对照研究

Risk factors for preterm delivery among Kunshan people:A case-control study

目的：探讨过去6年内昆山地区早产儿危险因素。方法：以2004-2009年昆山市妇幼保健所在登记孕产妇与产后新生儿为研究对象,排除母亲孕前糖尿病和及其他因素,以早产儿母亲年龄、民族为配对条件,采用1∶3配比的病例对照研究。结果：多因素条件Logistic回归分析表明,母亲职业为干部/科技工作者/军人（OR=0.70,95%CI：0.49~0.99）、有人工流产史、产前检查6次以上、父亲文化程度为大专及以上（OR=0.42,95%CI：0.19~0.89）是早产儿的保护性因素;而母亲为经产妇（OR=1.27,95%CI：1.01~1.62）、男性胎儿（OR=1.53,95%CI：1.28~1.83）是早产儿的危险因素;未发现随着父亲吸烟、饮酒剂量增加而有母亲生产早产儿风险的增加。结论：母亲职业为干部/科技工作者/军人、有人工流产史、产前检查6次及以上、父亲文化程度为大专及以上是早产儿保护性因素;而母亲有生产史、男性胎儿是早产儿的危险因素。

Objective：To identify factors associated with risk of preterm delivery over the past 6 years in Kunshan area.Methods：This population-based case-control study was conducted between 2004 and 2009 in the area of Kunshan,southern part of the Jiangsu Province.Our analyses included 667 cases and 2001 maternal age-matched controls who were randomly selected from the normal birth week population.Potential risk factors for preterms included maternal prepregnancy weight and height,educational level,career,menarche,parity,induced abortion,antepartum care freqency and infant gender,father＇s factors included father＇s age while the infant born,education level,career,smoking and drinking status.Results：Multivariate conditional Logistic regression analysis were performed,after adjusting for potential confounding factors,the results showed evidence that mothers career as official or researcher or soldier（OR=0.70,95%CI：0.49~0.99）,induced abortion,antepartum care more than six times,paternal received junior college or university education（OR=0.42,95%CI：0.19~0.89） were protective factors for preterm delivery.Maternal is multipara（OR=1.27,95%CI：1.01~1.62） and male fetal（OR=1.53,95%CI：1.28~1.83） were risk factors for preterm delivery.No evidence indicates that with the increasing paternal smoking and alcohol consumption,with increasing the risk of preterm delivery.Conclusion：These results showed that maternal career as official or researcher or soldier,induced abortion,antepartum care more than six times were the protective factors for preterm delivry.Paternal received junior college or university education could reduce preterm delivery.And maternal is a multipara,male fetal appeared the risk factors for preterm delivery.