尼莫地平与氟桂利嗪治疗偏头痛的临床观察

A comparative study of nimodipine and flunarizine in treatment of migraine

目的:观察尼莫地平与氟桂利嗪治疗偏头痛的临床效果。方法:随机将190例偏头痛患者分为两组,观察组96例,给予尼莫地平30 mg/次,每日3次,对照组92例给予氟桂利嗪5 mg/次,每晚1次。结果:尼莫地平与氟桂利嗪治疗偏头痛的临床疗效差异无统计学意义(P>0.05),但不良反应差异有统计学意义(P<0.05)。结论:尼莫地平与氟桂利嗪治疗偏头痛的临床疗效相当,但尼莫地平不良反应较氟桂利嗪少,是目前较为理想的防治偏头痛的药物。

Objective：To explore the clinical efficacy of nimodipine and flunarizine in treatment of migraine.Methods：190 patients with the diagnosis of migraine were randomly divided into experimental group（n=96） and control group（n=92）.It was treated for nimodipine（30 mg,three times daily） in experimental group.The control group was treated with flunarizine（5 mg,nightly）.Results：There was no significant difference between two groups in efficacy（P0.05）.But significant difference was found in side-effect（P0.05）.Conclusions：Nimodipine showed the same effect in treatment of migraine with flunarizine and had less side-effects than flunarizine.Nimodipine was thought to be an ideal drug for migraine.