异维A酸抑制痤疮患者外周血白细胞介素6的表达

Inhibition of isotretinoin capsules on interleukin 6 in the treatment of acne

目的探讨异维A酸对痤疮患者外周血白细胞介素6(Interleukin-6,IL-6)的影响。方法选择重度痤疮患者30例,口服异维A酸胶丸治疗,10mg/次,2～3次/d,12周为一疗程,采用酶联免疫吸附试验(ELISA)检测患者治疗前后血清中IL-6的水平,另外选择30名健康体检者作为正常对照。结果治疗前重度痤疮患者血清中IL-6的水平明显高于正常对照者(t=7.75,P<0.01);治疗后重度痤疮患者血清中IL-6的水平较治疗前明显降低(t=-6.78,P<0.01);治疗后重度痤疮患者血清中IL-6的水平与正常对照组相比,差异无统计学意义(t=1.88,P=0.0653)。结论异维A酸能抑制痤疮患者外周血IL-6的过度表达,这可能是异维A酸治疗痤疮的作用机制之一。

Objective To investigate the effect on interleukin 6（IL-6） in the treatment of severe acne by isotretinoin capsules.Methods Thirty adult patients with acne and 30 health control were sequentially enrolled in this study.The patients were treated with isotretinoin capsules（10 mg,bid to tid） for 12 weeks.Expression level of IL-6 was decected by Elisa methods.Results The serum level of IL-6 in severe acne patients was statistically significantly higher than that of healthy control group （t=7.75,P0.001）.The serum level of IL-6 in severe acne patients after treatment group was statistically significantly higher than that of before treatment group（t=-6.78,P0.001）.The serum level of IL-6 in after treatment group was not significantly different with healthy control group（t=1.88,P= 0.0653）.Conclusion Our results show that isotretinoin could inhabit the over expression of IL-6.These changes could be part of the therapeutic effects of isotretinoin on acne.