泮托拉唑联合生长抑素治疗急性胰腺炎的临床研究

Clinical effects of pantoprazole combined with somatostatin on patients with acute pancreatitis

目的观察泮托拉唑联合生长抑素治疗急性胰腺炎的疗效。方法将2008年6月至2011年7月收治的120例急性胰腺炎患者,随机分为对照组和治疗组,每组各60例。治疗组在常规禁食、胃肠减压等治疗的基础上,生长抑素首次静脉注射250μg,然后改用500ml0.9%氯化钠注射液+3000μg生长抑素经微量静脉泵持续静脉泵注,泵速250μg/h,轻度患者连续5～7d,重度患者连续7～14d。NS 100ml+泮托拉唑40mg,静脉滴注,2次/d。对照组除不用泮托拉唑外其余均与治疗组相同。观察两组的疗效。结果治疗组显效37例,有效19例,无效4例,总有效率为93.3%;对照组显效25例,有效17例,无效18例,总有效率为70%。两组总有效率比较差异有统计学意义(P<0.05)。两组患者在治疗期间均无明显不良反应。结论泮托拉唑联合生长抑素治疗急性胰腺炎的疗效优于单独应用生长抑素,值得临床推广应用。

Objective To observe the therapeutic efficacy of pantoprazole combined with somatostatin on patients with acute pancreatitis.Methods 120 cases patients with acute pancreatitis from June 2008 to July 2011 were randomly divided into the treatment group and control group,60 cases in each group.In the treatment group,fasting,gastrointestinal decompression and other treatment,based on the first intravenous injection of somatostatin 250 μg,and then add 3000 μg somatostatin to 500 ml normal saline solution through microvein pump continuous intravenous infusion,pump speeds 250 μg/h,mid patients for 5～7 d,serious patients for 7～14 d.Add 40 mg pantoprazole to 100 ml normal saline solution by intravenous perfusion,bid.In the control group,except was not use pantoprazole,and the others the same as the treatment group.Observed the curative effect of two groups.Results Treatment group,37 cases were markedly effective,19 cases effective,4 cases ineffective,the total effective rate was 93.3%.The control group,25 cases were markedly effective,17 cases effective,18 cases ineffective,the total effective rate was 70%.The total effective rate of two group had difference（P 0.05）.During treatment were not significantly adverse reactions on patients of two groups.Conclusion The therapeutic efficacy of pantoprazole combined with somatostatin on patients with acute pancreatitis better than somatostatin alone,it to be worth generalization at clinical.