血清CRP鉴别诊断小儿社区获得性肺炎的系统评价

Systematic review of the utility of serum c-reactive protein in differentiating diagnosis of children community-acquired pneumonia

目的探讨血清C反应蛋白(C-reactive protein,CRP)鉴别诊断小儿社区获得性肺炎(Community-acquired pneumonia,CAP)的效能和临床应用前景。方法收集有关血清CRP鉴别诊断小儿CAP的临床研究进行Meta分析。结果细菌性肺炎患者血清CRP阳性率高于支原体肺炎患者、病毒性肺炎和正常健康人(均P<0.01);支原体肺炎患者血清CRP阳性率亦明显高于病毒性肺炎和正常健康人(均P<0.01);而病毒性肺炎患者血清CRP阳性率则高于正常健康人(P=0.010)。结论细菌性肺炎患者血清CRP显著高于支原体肺炎患者、病毒性肺炎患者及正常健康人。

Objective To evaluate the utility and clinical value of serum C-reactive protein in differentiating diagnosis of children community-acquired pneumonia（CAP）.Methods Articles related to the utility of serum C-reactive protein in differentiating diagnosis of children CAP were selected.Data analysis was conducted by RevMan 5.0.25 and STATA 10.0 software.Results The results of meta-analysis showed that the positive rate of serum CRP in patients with bacterial pneumonia significantly higher than that of mycoplasma pneumonia patients,viral pneumonia and normal healthy children（all P0.01）.The positive rate of serum CRP in patients with mycoplasma pneumonia significantly higher than that of viral pneumonia patients and normal healthy children（all P0.01）.In addition,the positive rate of serum CRP in viral pneumonia patients were higher than normal healthy children（P=0.01）.Conclusion Serum CRP in patients with bacterial pneumonia are significantly higher than that of mycoplasma pneumonia,viral pneumonia patients and normal healthy people.