2010年天津市健康人群乙型病毒性肝炎病毒血清流行病学分析

Seroepidemiology of hepatitis B in healthy population in Tianjin,2010

目的了解2010年天津市不同年龄段的健康人群乙型病毒性肝炎(乙肝)病毒(HBV)感染或免疫状况。方法根据年龄段和职业,在全市16个区(县)中采取分层整群随机抽样方法确定目标人群,对目标人群采用统一的调查表,调查登记与HBV感染和乙肝疫苗免疫相关的信息。结果 1～59岁健康人群HBV表面抗原(HBsAg)、表面抗体(抗-HBs)和核心抗体阳性率分别为2.63%、47.63%和10.15%;HBsAg阳性率:男性3.52%、女性1.73%,差异有统计学意义(χ2=13.78,P<0.05),且随年龄的增长而逐渐升高,差异有统计学意义(χ2=30.39,P<0.05);滨海三区最高(4.17%),市内六区最低(1.85%),地区间差异有统计学意义(χ2=9.59,P<0.05);农民最高(4.44%),<10岁儿童最低(0.38%)。抗-HBs阳性率:男性与女性基本一致,且随年龄的增长而显著降低,差异有统计学意义(χ2=302.06,P<0.05)。结论新抽样方法适于现时期入户采血难的形势,且研究结果同样具有代表性。

Objective To understand the current status of hepatitis B virus（HBV） infection among the healthy population in Tianjin.Methods The survey of HBV infection status and hepatitis B vaccination was conducted among the healthy population selected in 16 counties（district） in Tianjin with stratified cluster random sampling.Results The results showed that the positive rates of HBsAg,anti-HBs and anti-HBc were 2.63%,47.63% and 10.15% respectively.The positive rate of HBsAg was significantly higher in males（3.52%） than in females（1.73%） and increased with age（χ2=30.39,P0.05）;The positive rate of HBsAg varied with areas,which was highest in coastal area（4.17%） and lowest in urban area（1.85%）,the difference was statistical significant（χ2=9.59,P0.05）.The positive rate of HBsAg was highest in farmers（4.44%） and lowest in children aged 10 years（0.38%）.The positive rates of anti-HBs were similar between males and females,which declined with age.Conclusion The new sampling method was suitable for the serological surveillance of hepatitis B in the context of the difficulty existing in household survey for collecting blood sample and the result of the study was representative.