雌激素受体及孕激素受体在肝内及肝外胆管癌中的表达

Expression of estrogen receptor and progesterone receptor in intrahepatic and extrahepatic cholangiocarcinoma

目的对比研究雌激素受体（ER）、孕激素受体（PR）在肝内、外胆管癌中的表达情况。方法应用免疫组织化学法，检测24例肝内胆管癌和34例肝外胆管癌组织中ER和PR的表达水平。结果在肝内胆管癌中，ER和PR的阳性表达率分别为29％（7／24）和46％（11／24），组织学分级高分化组的9例中3例ER阳性表达，中分化组的11例中3例阳性表达，低分化组的4例中1例阳性表达；不同分级中，PR阳性表达分别为2、7、2例，各组织学分级间ER和PR的表达差异无统计学意义（均P〉0．05）。ER和PR在34例肝外胆管癌中均呈阴性表达。结论ER和PR在肝内、外胆管癌中的表达水平明显不同，仅表达于肝内胆管癌，可能参与了肝内胆管癌的发生过程。

Objective To investigate the expression of estrogen receptor （ER） and progesterone receptor （PR） in intrahepatic cholangiocarcinoma （ICCA） and extrahepatic cholangiocarcinoma （ECCA） comparatively. Methods The expression of ER and PR was detected in 24 specimens of ICCA and 34 specimens of ECCA by immunohistochemistry assay. Results The positive rates for ER and PR expression were 29 % （7/24） and 46 % （11/24） in ICCA specimens, respectively. 3 cases among 9 cases of high histological grade, 3 cases among l 1 cases of middle histological grade and 1 case among 4 cases of low histological grade expressed ER positively, while 2 cases, 7 cases and 2 cases expressed PR positively, respectively. The expression of ER and PR expressions showed no statistically significant differences between different histological grades of ICCA. ER and PR were all negative in 34 specimens of ECCA. Conclusion ER and PR show significant different expression between ICCA and ECCA, With exclusive positive expression in ICCA. ER and PR might be involved in the pathogenesis of ICCA.