不同病因的皮质下小梗死的危险因素比较

Comparison of Vascular Risk Factors in Patients with Small Subcortical Infarction Caused by Atherosclerosis or Small Artery Disease

目的观察皮质下小的脑梗死(small subcortical infarction,SSI)与颅内外大动脉病变的关系。比较动脉粥样硬化性与小动脉病变性ssI患者的危险因素的差异。方法连续收集住院的118例急性SSI患者,依据循证的缺血性卒中病因分型诊断标准停止卒中研究急性卒中治疗Org 10172试验(stop stroke study Trial of Org 10172 in Acute stroke Treatmentclassification System,SSS-TOAST)进行卒中分型,比较不同血管病因所导致的SSI的比例,分析不同病因惠者的血管性危险因素的差异。结果 118例急性SSI惠者中,动脉粥样硬化性者26例(22%)、小动脉病变者75例(64%),心源性、其他明确病因及病因不明确者17例(14%)。动脉粥样硬化病变者与小动脉病变者的主要血管性危险因素分布差异无统计学意义。结论 SSI患者的病因并非相同,以小动脉病变居多。动脉粥样硬化性和小动脉病变性ssI在血管危险因素分布之间差异无统计学意义。

Objective To analyze the association between small subcortical infarctions（SSls） and extracranial or intracranial artery disease. To compare the vascular risk factors in SSI caused by atherosclerosis and small artery disease. Methods Serial hospitalized patients with acute SSI were enrolled. Patients were classified into different groups according to the Stop Stroke Study Trial of Org 10172 in Acute Stroke Treatment Classification System. The frequencies of SSI with different causes and their vascular risk factors were collected and compared. Results Among total 118 patients with SS1, 26 were caused by atherosclerosis, 75 were caused by small-artery diseases, and 17 were caused by other causes. There were no significant differences of risk factors between the group of atherosclerosis and the group of small-artery diseases（P〉0.05）. Conclusion SSIs are caused by different etiologies but mainly small-artery diseases. There are no significant differences of vascular risk factors between SSI caused by atheroselerosis or small artery diseases.