幽门螺杆菌感染在肝硬化并发症患者中的分布状况调查

Investigation on the helicobacter pylori infection distribution in patients with liver cirrhosis

目的研究幽门螺杆菌(Hp)对肝硬化并发症患者的影响。方法本院279例肝硬化合并上消化道出血、肝性脑病、原发性肝癌均接受快速尿素酶试验和14C-尿素呼气试验进行Hp检测。结果 Hp感染与肝硬化合并上消化道出血、肝性脑病、原发性肝癌有不同程度的关系,尤其Hp阳性组中消化性溃疡伴出血、肝性脑病、原发性肝癌发生率均高于Hp阴性组。结论肝硬化患者中Hp感染与肝硬化并发症相关,根除Hp可能降低上消化道出血、肝性脑病、原发性肝癌的发生。

Objective To study the effect of helicobacter pylori infection in patients with hepatic cirrhosis-related complications. Methods Hp was examined in hepatic cirrhosis group of 279 patents with upper gastrointestinal hemorrhage, hepatic encephalopathy and primary liver carcinoma in our hospital by rapid urea test and 14C urea breath test. Results There were different degrees of relationship between Hp infection and hepatic cirrhosis group with upper gastrointestinal hemorrhage, hepatic eneephalopathy and primary liver carcinoma,which particularly the incidence of peptic ulcer with hemorrhage, hepatic encephalopathy and primary liver carcinoma in Hp positive patients were higher than in Hp nengative patients. Conclusion Hp infection in patients with cirrhosis is related to hepatic cirrhosis-related complications, and Hp eradication may reduce upper gastrointestinal hemorrhage, hepatic encephalopathy and primary liver carcinoma.