阻塞性睡眠呼吸暂停低通气综合征患者血浆食欲素A水平的研究

Plasma orexin-A levels in patients with obstructive sleep apnea-hypopnea syndrome

目的探讨血浆食欲素A水平在阻塞性睡眠呼吸暂停低通气综合征(OSAHS)患者中的变化及作用。方法纳入OSAHS伴肥胖者30例、单纯OSAHS者30例、健康肥胖者20例和正常对照者20例。对所有受试者进行多导睡眠仪监测,空腹采血测定血浆食欲素A的水平。结果 OSAHS组食欲素A水平高于非OSAHS组(F=12.57,P<0.01);而肥胖组与非肥胖组食欲素A水平无统计学差异(F=0.90,P>0.05)。OSAHS组食欲素A水平与微觉醒指数、呼吸暂停低通气指数、氧减指数、血氧饱和度小于90%睡眠时间占总睡眠时间比例均呈正相关(r=0.50、0.38、0.31、0.39,P均<0.05)。结论OSAHS患者血浆食欲素A水平升高,与病情严重程度正相关,食欲素A可能参与OSAHS患者睡眠觉醒的调节过程。

Objective To explore the changes and implications of plasma orexin-A levels in patients with obstructive sleep apneahypopnea syndrome （OSAHS）. Methods Polysomnography was performed in 30 obese OSAHS patients, 30 OSAHS patients without obese, 20 obese subjects and 20 normal healthy adults. The level of plasma orexin-A was measured with a radioimmunoassay kit. Results Plasma orexin-A levels were higher in patients with OSAHS compared with those without OSAHS （F=12.57, P〈0.01）. Plasma orexin-A levels correlated positively with the AHI,arousal index, SLT90%, ODI4 （r=0.50,0.38,0.31,0.39,P〈0.05）. However, plasma orexin-A level did not relate to BMI. Conclusion The plasma orexin-A levels in OSAHS patients are increased which may be involved in arousal mechanisms in patients with OSAHS.