CXCR4和MMP-13在非小细胞肺癌中的表达

Expressions and its significance of CXCR4 and MMP-13 in non-small cell lung carcinoma

目的检测趋化生长因子受体4(CXCR4)和基质金属蛋白酶-13(MMP-13)在非小细胞肺癌中的表达,探讨二者与非小细胞肺癌临床病理特征的关系,以期为临床工作提供理论支持。方法应用免疫组织化学技术检测75例非小细胞肺癌及50例正常肺组织中CXCR4和MMP-13的表达,探讨二者与肿瘤分化程度及淋巴结转移的关系。结果非小细胞肺癌中CXCR4和MMP-13表达的阳性率明显高于正常肺组织,CXCR4和MMP-13的表达与非小细胞肺癌的胸膜侵犯、分化程度及有无淋巴结转移密切相关,非小细胞肺癌中CXCR4和MMP-13的表达呈正相关。生存分析显示,CXCR4和MMP-13高表达患者的预后差。结论非小细胞肺癌中CXCR4和MMP-13高表达,二者共同促进肿瘤的发生发展,联合检测CXCR4和MMP-13可能与患者的预后有关。

Objective To investigate the protein expressions of CXCR4 and MMP-13, observe their relationship and clinical significance on development and metastasis in non-small cell lung carcinoma. Methods The protein expressions of CX- CR4 and MMP-13 were detected by immunohistochemistry in the non-small cell lung carcinoma and normal lung tissues. Their expression relationship and different pathological characters were analyzed in non,small cell lung carcinoma. Results The protein expressions of CXCR4 and MMP-13 were higher in the neoplasm than in normal lung tissues. Their expressions were correlated with pleura invasion, differentiation and lymph node metastasis. Positive correlation between CXCR4 and MMP-13 protein was found in neoplasm. Conclusion The higher expressions of CXCR4 and MMP-13 were found in non-small cell lung carcinoma. The synergistic effect of CXCR4 and MMP-13 may promote the development of neoplasm.