氯吡格雷对不稳定型心绞痛患者血浆炎症因子的影响

Effect of clopisogrel sulfate on the levels of inflammatory factors in patients with unstable angina pectoris

目的探讨氯吡格雷对不稳定型心绞痛患者血浆炎症因子的影响及疗效观察。方法选择72例不稳定型心绞痛患者,随机分为观察组和对照组。两组患者均按不稳定型心绞痛的治疗方案进行治疗,观察组在此基础上加用氯吡格雷75 mg,每天1次,连用2周。结果治疗2周后,两组患者血浆TNF-α、MMP-9和IL-6水平均较治疗前明显下降(P<0.05或P<0.01),且观察组下降的幅度较对照组更明显(P<0.05)。观察组控制心绞痛的总有效率明显优于对照组(χ2=5.67,P<0.05)。两组治疗期间均无明显的不良反应。结论氯吡格雷治疗不稳定型心绞痛是一种安全、有效的方法,其作用机制与其改善血管内斑块的炎症反应有关。

Objective To observe the effect of clopidogrel on levels of inflammatory factors in patients with unstable angina pectoris （UAD and the clinic effect. Methods All of 72 patients who were diagnosed as UAP were divided randomly into two groups as observation group and control group. All patients in both groups received the routine medicine treatment, and the observation group got extra treatment as taking colposogrel sulfate 75 mg orally once a day for two weeks. Results The levels of INF-α, MMP-9 and IL-6 decreased significantly in either group at two weeks after treatment （P 〈 0.05 or P 〈 0.01）, and the reducing was more obvious in observation group （P 〈 0.05）. During the treatment period, the total effective rate for angina peetoris of observation group was significantly higher than that of control group （X^2=5.67, P 〈 0.05）, and no obvious adverse reaction was observed in either group. Conclusion Clopisogrel sulfate shows safe and effective on patients with UAP. Maybe the mechanism relates to that clopisogrel sulfate has anti-inflammatory effect, and can improve blood vessel plaque inflammation.