期刊文献+
任意字段
题名或关键词
题名
关键词
文摘
作者
第一作者
机构
刊名
分类号
参考文献
作者简介
基金资助
栏目信息

一氧化氮合酶基因多态性与吉林省汉族人群冠心病的关系研究 被引量：1

Association study between the polymorphisms of nitric oxide synthase gene and coronary heart desease in Jilin Province
下载PDF
导出
摘要 目的研究内皮型一氧化氮合酶基因多态性与冠心病的关系。方法收集120例患有冠心病的患者和102例年龄、性别相匹配的健康对照者，采用聚合酶链反应和限制性片段长度多态性分析其多态性并确定基因型。结果冠心病组eNOS基因的（1T＋TG）基因型明显的高于正常对照组（OR=2．02，95％CI：1．09—3．75，P〈0．05），两组等位基因T差异具有统计学意义（OR=1．96，95％CI：1．14～3．36，P〈0．05）。结论eNOS基因G894T基因多态性与冠心病发病有关。 Objective To investigate the risk of coronary heart desease with endothelial constitutive nitric oxide synthase gene polymorphisms. Methods We investigated the G894T mutations in the eNOS gene in 120 Chinese patients with coronary heart desease and 102 age- and sex-matched healthy controls. Its genotype was defined by the polymerase chain reaction and restriction fragment length polymorphism analysis. Results The （TT＋TG） genotype of eNOS in the coronary heart desease group were higher than control group （OR = 2.02, 95%CI： 1.09-3.75, P 〈 0.05）.The allele gene T had statistical meaning in two group （0R=1.96, 95% CI： 1.14-3.36, P 〈 0.05）. Conclusion There is a synergistic effect of eNOS gene polymorphisms in patients with coronary heart desease.
作者 于薇
机构地区 长春市人民医院检验科
出处 《中国现代医生》 2012年第3期87-88,共2页 China Modern Doctor
关键词 冠心病 动脉粥样硬化 基因多态性 ENOS Coronary heart desease Atherosclerosis Polymorphism eNOS
分类号 R541.402 [医药卫生—心血管疾病]
  • 相关文献

参考文献6

  • 1Niwa M ,Inao S,Takayasu M ,el al. Time course of expression of three nitric oxide syntbase soforms after transient middle cerebralartery occlusion in rats[J]. Neurol Med Chir (Tokyo) ,2001,41 (2) :63-72.
  • 2Tsukada T,Yokoyama K,Arai T, et al. Evidence of association of the ecNOS gene poly morphism with plasma NO metabolite levels in humans[J]. Biochem Biophys Res Commun, 1998, 245 ( 1 ) : 190-193.
  • 3吕浩,雷霆,赵琳.脑梗死与一氧化氮合酶基因多态性的关系[J].中国临床康复,2004,8(22):4469-4471. 被引量：8
  • 4Macleod MJ,Dahiyat MT,Cumming A. No association between Glu/Asp polymorphism of NOS3 gene and ischemic stroke[J]. Neurology, 1999,53 (2) :418-420.
  • 5Shimasaki Y,Yasue H,Yoshimura M,et al. Association of the missense Glu298Asp variant of the endothelial nitric oxide synthase gene with myocardial infarction[J]. J Am Coll Cardial, 1998,31 (7) : 1506-1516.
  • 6Lembo G, De Luca N, Battagli C,et al. A common vLriant of endothelial nitric oxide Synthase (Glu298Asp) is an independent risk factor for carotid atheroselerosis[J]. Stoke, 2001,32 (3) : 735-740.

二级参考文献14

  • 1Yoshimura M, Yasue H, Nakayama M, et al. A missense Glu298Asp variant in the endothelial nitric oxide synthase gene is associated with coronary spasm in the Japanese. Hum Genet 1998; 103(1):65 -9
  • 2Shimasaki Y, Yasue H, Yoshimura M, et al. Association of the missense Glu298Asp variant of the endothelial nitric oxide synthase gene with myocardial infarction. J Am Coll Cardiol 1998; 31 (7): 1506- 10
  • 3Schulz GE. comparison of predicted and experimentedly determined secondary structure of adenykinase. Nature 1994; 250:140 - 2
  • 4Miyamoto Y, Saito Y, Kajiyama N, et al. Endothelial nitric oxide synthase gene ispositively associated with essential hypertension. Hypertension 1998; 32 ( 1 ): 3 - 8
  • 5Tesauro M, Thompson WC, Rogliani P, et al. Intracellular processing of endothelial nitric oxide synthase isoforms associated with differences in severity of car-diopulmonary diseases: cleavage of proteins with aspartate vs. glutamate at position 298. Proc
  • 6Shoji M, Tsutaya S, Saito RT, et al. Positive association of endothelial nitric oxide synthase gene polymorphism with hypertension in northern Japan. Life Sci 2000;66(26): 2557 - 62
  • 7Yasujima M, Tsutaya S, Shoji M. Endothelial nitric oxide synthase gene polymorphism and hypertension. Rinsho Byori 1998 46(12): 1199 -20
  • 8Lembo G, De Luca N, Battagli C, et al. A common variant of endothelial nitric oxide synthase(Glu298Asp) is an independent risk factor for carotid atherosclerosis. Stroke 2001; 32(3): 735 - 40
  • 9Markus HS, Ruigrok Y, Ali N, et al. Endothelial nitric oxide synthase exon 7ischemic cerebrovascular disease and carotid atheroma. Stroke 1998; 29(9):1908 - 11
  • 10MacLeod MJ, Dahiyat MT, Cumming A, et al. No association between Glu/Asp polymorphism of NOS3 gene and ischemic stroke. Neurology 1999; 53(2): 418 -20

共引文献7

同被引文献9

引证文献1

二级引证文献4

中国现代医生
2012年 第3期

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部