首发精神分裂症及其父母听觉ERP的研究

Study on auditory event--related potentials of first--episode schizophrenia and their parents

目的印证首发精神分裂症及其父母是否存在认知功能障碍，并探讨事件相关电位是精神分裂症的遗传素质标志还是状态性标志。方法从2010年1～12月期间在徐州市东方人民医院住院的患者中选取符舍CCMD-3精神分裂症诊断标准的首发患者60倒，作为患者组；选取精神分裂症患者生物学意义上的父母，共120例作为亲属组；选取无精神疾病家族史的健康志愿者作为对照组，共60倒。分别对三组进行ERP检测。所得数据应用SPSS13．0统计软件包处理分析，采用的主要统计学方法包括卡方检验、单因素方差分析和协方差分析。结果（1）患者组、亲属组和对照组闯N2、P3潜伏期和P3波幅差异均有统计学意义（均为P〈0．01）；（2）患者组的N2潜伏期长于对照组（P〈0．05），亲属组和时照组的各潜伏期相比差异无统计学意义（均为P〉0．05）；患者组和亲属组的P3波幅均明显低于对照组（均为P〈0．05），而患者组和亲属组P3波幅差异无统计学意义（P〉0．05）。结论（1）首发精神分裂症及其父母可能存在一定程度的认知功能障碍；（2）P3波幅倾向于精神分裂症的遗传素质性标志，N2潜伏期倾向于精神分裂症的状态性标志。

Objective To evaluate cognitive function in first--episode schizophrenic patients and their parents,and to explore whether the event--related potentials is the genetic or the state markers in schizophrenia. Methods Sixty patients with schizophrenia were consecutively recruited from the inpatients of the Department of Psychiatry,Xu Zhou City People,s Hospital of Eastern. They all met CCMD --3 criteria for schizophrenia. One hundred and twenty parents of the schizophrenic patients were consecutively recruited as relative group. Sixty healthy control subjects with no individual and familial history of mental illness were also recruited. The event--related potentials of them were examined respectively. All data were statistically analyzed by SPSS13.0 software. Chi-square test and analysis of variance and covariance were used to compare the eventrelated potentials among the three groups. Results （1） The N2,N3 latency and P3 latency of the patient group, relative group and the control group were all significantly different from each other （P 〈 0.01）. （2） The patient group was significant- ly different from the control group in N2 latency （P ~ 0.01）. The relative group had no significant difference from control group in the latency （P〈 0.05）. The amplitude P3 of the patients and relatives were both significantly different from the control group （P 〈 0.01）. The patient group was not different from the relative group in the P3 amplitude （P 〉 0. 05）. Conclusions The study supported the following points： （1）Both first--episode schizophrenic patients and their parents had defect in their functional recognition. （2）The P3 amplitude was possibly the genetic marker of schizophrenia,and the N2 latency was possibly the state marker of the schizophrenia.