有氧运动对肥胖女大学生外周血瘦素水平及瘦素受体mRNA表达的影响被引量：7

Effects of Aerobic Exercise Prescription to Leptin Levels and Leptin Receptor mRNA Expressions in Peripheral Blood of Female Obese College Students

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摘要目的:通过对肥胖女大学生实施12周有氧运动处方,检测受试者血浆瘦素水平及外周血单个核细胞瘦素受体mRNA的表达,探讨运动减肥的机理。方法:以60名肥胖女大学生作为受试者,实施有氧运动处方12周,分别在运动前、后对受试者的体重、体重指数、腰围和体脂含量进行测定;采用全自动生化分析仪测定血TG、TCH、HDL-C、LDL-C的含量及ELISA法检测血浆瘦素水平;应用RT-PCR法检测外周血单个核细胞瘦素长、短受体mRNA的表达。结果:运动后受试者体重、体重指数、腰围和体脂含量有明显减少,血TG、TCH、LDL-C含量降低,而HDL-C没有统计学意义的变化;血浆瘦素水平显著性降低;外周血单个核细胞瘦素长、短受体mRNA的表达均上调。结论:1)有氧运动导致血浆瘦素水平下降可能是机体为了维持自身体重稳定和能量代谢平衡的一种适应性反应,体内瘦素水平下降与体脂含量减少有密切关系。2)有氧运动促进体脂下降可能是通过长、短瘦素受体的表达上调来发挥生物学作用的。3)有氧大众健美操辅助力量练习可以作为一种有效的有氧运动处方,达到降低体脂的目的。 Objective： In order to discuss the possible mechanism of exercise weight loss,through detecting female obese college students＇ leptin levels and leptin receptor mRNA expressions in peripheral blood after implementation of 12-week aerobic exercise prescription.Methods： 60 female obese college students are tested respectively before and after the 12-week aerobic exercise prescription,which including weight,body mass index,waist circumference and body fat content;TG,TCH,HDL-C,LDL-C levels are analyzed by automatic biochemistry;Plasma leptin levels are analyzed by ELISA;And the length leptin receptor expressions of mononuclear cells in peripheral blood are analyzed by RT-PCR.Results： After the aerobic exercise,female obese college students＇ weight,body mass index,waist circumference and body fat content significantly decrease.TG,TCH and LDL-C in blood decrease,while HDL-C has not have any statistically significance;Serum leptin levels decrease remarkably;Leptin length receptor mRNA expressions of mononuclear cells in peripheral blood all increase.Conclusion：（1） The decreasing of plasma leptin caused by aerobic exercise is an adaptive response that the body maintains the stability of weight and the balance of energy metabolism.The decline of leptin levels are closely related to body fat content.（2）Aerobic exercise decreases body fat,which may be through the upregulation of the length leptin receptor expressions.（3）Aerobic exercises assisting strength exercises can be used as an effective aerobic exercise prescription.

作者许之屏柳维林王萍秀胡煜金育强

机构地区湖南师范大学体育学院湖南女子学院体育教学部

出处《北京体育大学学报》 CSSCI 北大核心 2011年第11期58-61,共4页 Journal of Beijing Sport University

基金国家大学生创新性实验计划项目"有氧运动处方对肥胖女大学生身心健康影响的研究"(编号:091054247) 2011年湖南省科技厅科研项目(编号:2011FJ6045)

关键词有氧运动处方肥胖瘦素瘦素受体mRNA aerobic exercise prescription obese leptin leptin receptor mRNA

分类号 R87 [医药卫生—运动医学]

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