老年人非酒精性脂肪性肝病与颈动脉粥样硬化的相关性研究

The Association Between Nonalcoholic Fatty Liver Disease of the Older and Carotid Atherosclerosis

目的:非酒精性脂肪性肝病(NAFLD)和颈动脉粥样硬化(CAS)是老年人的常见病,本研究进一步探讨老年人中非酒精性脂肪性肝病(NAFLD)与颈动脉粥样硬化(CAS)的关系及临床意义。方法:根据超声检查结合病史将研究对象划分为老年非酒精性脂肪性肝病组和老年正常肝脏组,检查收缩压、舒张压、空腹抽血化验包括空腹血糖(GLU)、血胆固醇(TC)、甘油三酯(TG)、高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白胆固醇(LDL-C)、谷丙转氨酶(ALT)等;超声检测颈动脉内膜中层厚度(IMT)和颈动脉粥样斑块情况。结果:老年非酒精性脂肪性肝病组的甘油三酯(TG)、低密度脂蛋白胆固醇(LDL-C)、谷丙转氨酶(ALT)明显高于非脂肪肝组(P<0.05);非酒精性脂肪性肝病组的颈动脉内膜中层厚度与非脂肪肝组存在显著差异(P<0.05),但是,在颈动脉粥样斑块发生率(%)方面,两组之间差异无统计学意义。结论:老年非酒精性脂肪性肝病与颈动脉内膜中层增厚密切相关。

Objective：To observe the association between nonalcoholic fatty liver disease of the older and carotid atherosclerosis. Methods：To test the objects with physical examination,serum glucose,serum lipid-profile and ultrasonographic examination of liver,and measuring the intima thickness of the carotid artery and detecting of atherosclerotic plaque by ultrasound. Results：The serum trilyceride（TG）,low-density lipoprotein cholesterol（LDL-C） and SGPT in the nonalcoholic fatty liver disease of the older were significantly higher than the group without fatty liver（P0.05）.The intima thickness of the carotid artery from the patients are significantly higher than the group without fatty liver（P0.05）,but the prevalence rate of carotid atherosclerotic plaque from the patients is not different from the group without fatty liver. Conclusions：Comparing patients with normal liver,the older patients with nonalcoholic fatty liver disease have thicker carotid intima.