摘要
Molecular targeted therapy (MTT), using chemicals of low molecular weight, monoclonal antibodies, and/or polypep- tides to interfere with specific signaling pathways in cancer cells, causes inhibition of tumor progression. Clinical evi- dence has demonstrated that MTT has promising potential in not only killing tumors but also inducing tumor cells to differentiate into normal cells, leading to cure of the patients. Furthermore, MTT leads to potent inhibition of oncogenic signals. The delay of tumor progression makes the patients "survive with tumor". Thus, in the future it is possible that cancer becomes a chronic disease much like diabetes and hypertension. This article reviews the theory on molecular targeted therapy, its features and future direction, and con- tributions in the field from Chinese scientists.
Molecular targeted therapy (MTT), using chemicals of low molecular weight, monoclonal antibodies, and/or polypep- tides to interfere with specific signaling pathways in cancer cells, causes inhibition of tumor progression. Clinical evi- dence has demonstrated that MTT has promising potential in not only killing tumors but also inducing tumor cells to differentiate into normal cells, leading to cure of the patients. Furthermore, MTT leads to potent inhibition of oncogenic signals. The delay of tumor progression makes the patients "survive with tumor". Thus, in the future it is possible that cancer becomes a chronic disease much like diabetes and hypertension. This article reviews the theory on molecular targeted therapy, its features and future direction, and con- tributions in the field from Chinese scientists.
