摘要
Atrial fibrillation （AF） remains one of the leading causes of morbidity and mortality in the world which are related to palpita- tions, fainting, congestive heart failure or stroke. The mechanism for atria/fibrillation has been identified as electrical remod- eling, structure remodeling and intracellular calcium handling remodeling, microRNAs （miRNAs） have recently emerged as one of the important factors in regulating gene expression. So far, thousands of miRNA genes have been found in diverse ani- mals with the function of regulating cell death, cell proliferation, haematopoiesis and even participate in the processing of car- diovascular disease. In this review, we summarize the mechanism of AF and the association of microRNAs network with AF. We provide a potential perspective of miRNAs as the therapeutic target for AF.
Atrial fibrillation(AF) remains one of the leading causes of morbidity and mortality in the world which are related to palpitations,fainting,congestive heart failure or stroke.The mechanism for atrial fibrillation has been identified as electrical remodeling,structure remodeling and intracellular calcium handling remodeling.microRNAs(miRNAs) have recently emerged as one of the important factors in regulating gene expression.So far,thousands of miRNA genes have been found in diverse animals with the function of regulating cell death,cell proliferation,haematopoiesis and even participate in the processing of cardiovascular disease.In this review,we summarize the mechanism of AF and the association of microRNAs network with AF.We provide a potential perspective of miRNAs as the therapeutic target for AF.
基金
supported by the National Natural Science Foundation of China (Grant No. 81100122) to Zhang Ying
China Postdoctoral Special Science Foundation to Dong DeLi
National Basic Research Program of China (Grant Nos. 2007CB512000 and 2007CB512006) to Yang BaoFeng
