CD36在冠状动脉成形术后再狭窄中的临床意义

Effects of CD36 on in-stent restenosis in coronary artery

目的探讨CD36与冠脉支架介入治疗术后冠状动脉再狭窄的关系。方法选择308例行冠脉支架置入术的冠心病患者,分别于术前,术后1个月,6个月,采用ELISA法检测患者血清CD36、C反应蛋白(CRP)、VCAM-1的表达水平。按照冠状动脉狭窄评分(CSA)标准,将29例支架术后再狭窄患者分为A、B、C3组。结果与术前比较,冠心病患者术后1个月,6个月的CD36、CRP、VCAM-1水平均有显著降低;与术后未狭窄组比较,术后再狭窄组上述指标则明显增高;CD36、CRP、VCAM-1水平随CSA评分的升高而升高;CD36、CRP、VCAM-1与术后再狭窄呈正相关性。结论 CD36、CRP、VCAM-1与支架术后冠状动脉再狭窄形成有一定的相关性,对其表达水平的检测有助于冠脉支架术后临床疗效的评价。

Objective To study the effect of CD36 on coronary artery restenosis after coronary artery stent interpolation（CASI）.Methods Three hundred and eight patients with coronary artery disease received CASI.Hematology levels of CD36,CRP,VCAM-1of all 308 patients were measured by enzyme-linked immunosorbent assay（ELISA）,respectively,before,1 and 6 months after CASI.According to CSA criteria,29 cases of coronary artery restenosis after CASI were classified into group A,group B and group C.Results Compared with the values before the interventional therapy,hematology levels of CD36,CRP,VCAM-1 among the selected patients,without exception,decreased significantly 1 month and 6 months after CASI.In the cases o f post-CASI coronary artery restenosis,the previously mentioned corresponding items increased evidently,and the values were positively correlated with CSA grade and severity of CAD.Conclusion CD36,CRP,VCAM-1 are related to coronary artery restenosis after CASI.The measurement of hematology levels of it is some value in the prognosis of coronary artery restenosis.