舒芬太尼和瑞芬太尼应用于腹腔镜胆囊切除术的对比

The comparison of methods of Remifentanil and Sufentanil after laparoscopic cholecystectomy

目的研究探讨舒芬太尼与瑞芬太尼应用于腹腔镜胆囊切除术苏醒后躁动情况对比。方法选择2005年9月至2010年9月我院接受腹腔镜胆囊切除术120例ASA分级Ⅰ～Ⅱ的患者作为观察对象,按照随机分组原则将所有观察对象分为治疗组与对照组各60例,所有患者气管插管全麻下进行腹腔镜手术,治疗组术毕前30min给予0.35μg/kg舒芬太尼静脉推注,对照组采用0.2μg/kg瑞芬太尼静脉推注维持麻醉。对比两组手术结束时(T1),拔管时(T2)、拔管后10min(T3)各时点的躁动评分(RS)、镇静评分(RSS)、心率、血压及不良反应的发生。结果治疗组各三个观察时点RS、RSS评分相比对照组更优,患者躁动少,清醒完全(P<0.01),对照组心率、血压T2、T3时点相比差异有统计学意义(P<0.01),治疗组差异无统计学意义(P>0.05),对照组5例出现苏醒后头晕、恶心、呕吐不良反应。结论舒芬太尼对比瑞芬太尼在全麻手术苏醒期躁动少,苏醒质量高,不良反应少,镇痛作用时间久。

Objective To investigate the restlessness of 2 methods of Remifentanil and Sufentanil after laparoscopic cholecystectomy.Methods Select 120 patients in ASA Ⅰ~Ⅱundergoing electve laparoscopic cholecystectomy were randomly assigned into 2 groups with 60 cases each.Sufentanil 0.35 μg/kgwas used for study group whereras,Remifentanil 0.2 μg/kg for control group to maintain anesthesia 30 minitues before end of the surgery estlessness score（RS）.Ramsaym Sedative Score（Rss）,heart rate（HR） were recorded at 30 minutes after drug administ ration（T1）,during extubation（T2）and 10 minitues（T3） after extubation,in addition that the side effects were observed during all time along.Results There were significantly differences of RS,RSS in 2 groups,the patients in study group were apparently less restless during emergence,meanwhile there were remarkble differences in the rate of heart during T2 and T3 in control group of which with the side effects were nausea and vomiting.Conclusion The application of Sufentanil can safely and perfectly prevent the restlessness during emergence which will produce few side effects and has effectively intravenous analgesia after operation.