口腔内冷水刺激反应的功能性磁共振成像研究

Functional activity mapping during intraoral stimuli with cold water:with fMRI

目的:探讨口腔冷水刺激时的大脑皮层区定位。方法:选取13名健康志愿者,4℃冷水刺激,并以室温水组作为空白对照。利用水传递装置自上下唇进入口腔黏膜水刺激,并采用水刺激信号减静息信号的组块设计方法,采集冷水刺激时全脑血氧水平依赖对比的fMRI扫描数据,并用SPM99软件包进行结果的数据分析。结果:激活双侧眶额皮层(orbitalfrontal cortex,OFC)(BA11)、BA44、口腔躯体感觉运动皮层、顶叶、前运动皮层PMC(BA6)。右侧舌回、扣带回、颞叶和左侧枕叶的楔叶激活。结论:1.口腔冷水刺激可以激活大脑皮层的相关区;2.冷水刺激激活与口腔内水愉快行为评估有关的OFC。

Objective： To evaluate the feasibility of fMRI on the location of brain regions related to stimulation with cold water,and compare the different brain regions under between intra-oral 4°C cold and 23°C water stimulation.Methods： Thirteen healthy volunteers were selected to perform the fMRI study.4°C（group C-g-L） deionized water stimuli was delivered to the subject＇s mouth through polythene tubes that were held between the left of lips.Group W-g-L served as control.Block designed fMRI scan covering the whole brain was carried out.The fused cross-sectional map between the two groups C-g-L /W-g-L were compared.Results： Under cold stimulation,the following brain locations were bilateral activated： orbitalfrontal cortex（OFC）（BA11）,BA44,pre/post-central gyrus oral sensory/motor,parietal lobule,PMC（BA6）,and the following locations were unilateral activated： right ACC（BA24）,lingual gyrus,temporal lobe,midbrain red nucleus and occipital lobe.Compared groups C-g-L/W-g-L,overlapping brain areas included pre/post-central gyrus oral sensory/motor,ACC,insula/operculum.Conclusions： 1.The volume of activation was remained significantly when cold water was contrasted with warm water.This indicates that specific functional regions of the human brain cortex can be activated in fMRI study under cold stimulation;2.Cold stimulation might activate OFC involved in hedonic or reward value of water.