早期机械通气配合亚低温对重型颅脑损伤疗效的影响

Therapeutic effect of early mechanical ventilation with mild hypothermia on severe head injury

目的探讨应用早期机械通气配合亚低温治疗重型颅脑损伤的疗效。方法 2009年1月～2011年1月,将我科收治的50例重型颅脑损伤患者随机分为联合组(早期机械通气配合亚低温治疗)和对照组(早期机械通气治疗)各25例,比较两组患者血气变化情况及预后情况。结果观察组的PaO2、SaO2明显高于对照组,PaCO2明显低于对照组,差异有统计学意义(P<0.05);观察组的预后有效率明显高于对照组,差异有统计学意义(P<0.05)。结论早期机械通气配合亚低温对重型颅脑损伤具有较好的预后效果,能明显改善患者的血气指标,值得临床推广和应用。

Objective To investigate the effect of early mechanical ventilation with mild hypothermia on severe head in- jury. Methods All of 50 patients with severe traumatic brain injury were randomly divided into the combined group （early hypothermia treatment with mechanical ventilation） and the control group （early mechanical ventilation） of the 25 cases from January 2009 to January 2011, and two groups were compared blood gas changes and prognosis. Results The com- bined group of PaO2, SaO2 were significantly higher than the control group, and PaCO2 was significantly lower than the control group, the difference was statistically significant （P〈0.05）. The prognosis of the observation group was significantly higher efficiency, and the difference was statistically significant （P〈0.05）. Conclusion Early mechanical ventilation with mild hypothermia in treatment of severe head injury has good prognosis, and can significantly improve the patient＇s blood gas analysis, should be widely promoted and applied.